A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone
AUTOR(ES)
Stark, Lucy M.
FONTE
National Academy of Sciences
RESUMO
Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=514435Documentos Relacionados
- A concise, total synthesis of the TMC-95A/B proteasome inhibitors
- Catalyzed and non-catalyzed synthesis of bioactive monastrol
- A concise synthesis of the 1,6-disubstituted eudesmane sesquiterpene carbon skeleton
- A concise enantioselective synthesis of (+)-endo-brevicomin accomplished by a tellurium/metal exchange reaction
- A concise total synthesis of (R)-fluoxetine, a potent and selective serotonin reuptake inhibitor
