A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain

AUTOR(ES)

Aravind, L

FONTE

BioMed Central

RESUMO

This study characterizes the KAP protein family - a newly identified sub-group of the P-loop NTPases, which have transmembrane helices inserted into the P-loop NTPase domain. Their unusual phyletic distribution suggests KAP proteins were transferred from bacteria to animals by horizontal gene transfer.

Documentos Relacionados

• X-ray structure of HPr kinase: a bacterial protein kinase with a P-loop nucleotide-binding domain
• Active site comparisons highlight structural similarities between myosin and other P-loop proteins.
• The Third P-loop Domain in Cytoplasmic Dynein Heavy Chain Is Essential for Dynein Motor Function and ATP-sensitive Microtubule Binding
• Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop
• Identification of 23S rRNA nucleotides neighboring the P-loop in the Escherichia coli 50S subunit.