A new mutation in 16S rRNA of Escherichia coli conferring spectinomycin resistance.

AUTOR(ES)

Johanson, U

RESUMO

We report a novel mutation, C1066U in 16S rRNA which was selected for resistance to spectinomycin, an antibiotic which inhibits ribosomal translocation. The minimal inhibitory concentration (MIC) of spectinomycin determined for this mutant (15 micrograms/ml) is greater than with the wild-type plasmid (5 micrograms/ml) but lower than with the well known C1192U mutation (> 80 micrograms/ml). The C1066U mutation also increases the cells sensitivity to fusidic acid, another antibiotic which inhibits translation at the translocation stage, whereas C1192U is unchanged relative to the wild type. We discuss why the acquisition of resistance to one of these drugs is often associated with hypersensitivity to the other.

Documentos Relacionados

• Spectinomycin Resistance in Neisseria spp. Due to Mutations in 16S rRNA
• 16S rRNA Mutation-Mediated Tetracycline Resistance in Helicobacter pylori
• Mechanisms of Streptomycin Resistance: Selection of Mutations in the 16S rRNA Gene Conferring Resistance
• Spectinomycin resistance due to a mutation in an rRNA operon of Escherichia coli.
• 16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium