A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Protein Expression from Open Reading Frame 2 and an Adjacent Reading Frame during Productive Infection
AUTOR(ES)
Jiang, Yunquan
FONTE
American Society for Microbiology
RESUMO
The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5′ terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or an adjacent reading frame that lacks an initiating ATG (reading frame C). Since the LR mutant and wild-type BHV-1 express similar levels of LR RNA, we conclude that LR protein expression plays an important role in regulating the latency reactivation cycle in cattle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=353721Documentos Relacionados
- The Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Programmed Cell Death
- The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression.
- A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Disrupts the Latency Reactivation Cycle in Calves
- Alternative Splicing of the Latency-Related Transcript of Bovine Herpesvirus 1 Yields RNAs Containing Unique Open Reading Frames
- Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames.