A Mathematical Model of Interference for Use in Constructing Linkage Maps from Tetrad Data
AUTOR(ES)
King, J. S.
RESUMO
In determining genetic map distances it is necessary to infer crossover frequencies from the ratios of recombinant and parental progeny. To do this accurately, in intervals where multiple crossovers may occur, a mathematical model of chiasma interference must be assumed when mapping in organisms displaying such interference. In Saccharomyces cerevisae the model most frequently used is that of R. W. Barratt. An alternative to this model is presented. This new model is implemented using a microcomputer and standard numerical methods. It is demonstrated to fit ranked tetrad data from Saccharomyces more closely than the Barratt model and thus generates more accurate estimates of map distances when used with two-point data. A computer program implementing the model has been developed for use in calculating map distances from tetrad data in Saccharomyces.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1204647Documentos Relacionados
- Maximum Likelihood Estimation of Linkage and Interference from Tetrad Data
- Estimating Interference and Linkage Map Distance from Two-Factor Tetrad Data
- Comment concerning Maximum Likelihood Estimation of Linkage and Interference from Tetrad Data
- Use of plasmid R68.45 for constructing a circular linkage map of the Rhizobium trifolii chromosome.
- The Detection of Linkage in Tetrad Analysis
