A growing burden: the pathogenesis, investigation and management of non‐alcoholic fatty liver disease
AUTOR(ES)
Riley, P
FONTE
BMJ Group
RESUMO
Non‐alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder in western countries, and its incidence is increasing. This review outlines the significant health burden posed by NAFLD and discusses what is presently known about its pathogenesis, including the roles of the metabolic syndrome, obesity, insulin resistance, hepatic steatosis, reactive oxygen species, inflammatory cytokines and adipocytokines. The way in which NAFLD is clinically diagnosed is described, and areas of uncertainty surrounding its investigation are identified, before discussing the relative merits of the limited treatment options available and looking ahead to potential therapeutic strategies for the future.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2095560Documentos Relacionados
- SARCOPENIA AND SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE
- The association of vitamin D deficiency with non-alcoholic fatty liver disease
- Transient elastography in patients with non‐alcoholic fatty liver disease (NAFLD)
- Non‐alcoholic fatty liver disease in patients with HCV genotype 4
- Non-alcoholic fatty liver disease and thrombocytopenia IV: its association with granulocytopenia