A group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule.
AUTOR(ES)
Wyman, J
RESUMO
The binding of ligands by a macromolecule can be well described by a group of potentials derivable from the energy and of which the original binding potential is one. The group is Abelian and is isomorphic with a group of symmetries. Each member corresponds to a particular set of experimental conditions--system open to some, closed to others, of the ligand-and the group as a whole is an immediate source of all possible linkage relations applicable to the macromolecule. Seen in terms of information theory it can be interpreted as a program for the response of the macromolecule to its ligands according to the conditions with which it is faced. The group provides a ready formulation of the effect of a ligand on the equilibrium constant for a reaction involving a set of macromolecules, and it leads to a clear-cut distinction between true and pseudolinkage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432556Documentos Relacionados
- Determination of the distance between two spin labels attached to a macromolecule.
- THERMODYNAMIC POTENTIALS OF SYMMETRICAL ELECTROLYTES
- Thermodynamic Potentials and Natural Variables
- A Probabilistic Approach to Cooperativity of Ligand Binding by a Polyvalent Molecule
- Thermodynamic and kinetic cooperativity in ligand binding to multiple sites on a protein: Ca2+ activation of an ATP-driven Ca pump.