A Functional cra Gene Is Required for Salmonella enterica Serovar Typhimurium Virulence in BALB/c Mice

AUTOR(ES)

Allen, James H.

FONTE

American Society for Microbiology

RESUMO

A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad−, is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129–134, 1998). Here, evidence is presented that the mutation in SR-11 Fad− that renders the strain avirulent is in the cra gene, which encodes the Cra protein, a regulator of central carbon metabolism.

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