A expressão e atividade da NAD(P)H oxidase em ilhotas pancreáticas de ratos tratados com dieta hiperlipídica. / NAD(P)H oxidase expression and activity in pancreatic islets from rats treated with high fat diet.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Feeding animals with high fat diet containing lard causes obesity, insulin resistance and dysfunction of pancreatic beta cells. High fat diet induces oxidative stress and modulates NAD(P)H oxidase expression and activity in many tissues. This enzyme may be involved in many pathophysiological processes. The objective of this study was to evaluate the action of high fat diet on NAD(P)H oxidase activity and expression and if this fact can be connected to the beta cell dysfunction reported in the literature on this animal model. In pancreatic islets of rats fed the high fat diet apoptosis was reduced, glucose metabolism increased, insulin secretion elevated at high glucose, protein expression of NAD(P)H oxidase subunits reduced and the superoxide production was diminished. There was no difference between the groups for oxidative stress markers. It is possible that the enzyme has a role in the process of insulin secretion. Probably the islets are regulating their activity and function to compensate the deleterious effect of lard.

ASSUNTO(S)

physiology ilhotas de langerhans estresse oxidativo nad(p)h oxidase rats islets of langerhans superoxide radical radical superóxido fisiologia huger fat diet nad(p)h oxidase dieta hiperlipídica ratos oxidative stren

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