A different recruitment of the lateral and basolateral amygdala promotes contextual or elemental conditioned association in Pavlovian fear conditioning
AUTOR(ES)
Calandreau, Ludovic
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
Convergent data suggest dissociated roles for the lateral (LA) and basolateral (BLA) amygdaloid nuclei in fear conditioning, depending on whether a discrete conditioned stimulus (CS)–unconditional stimulus (US) or context–US association is considered. Here, we show that pretraining inactivation of the BLA selectively impaired conditioning to context. In contrast, inactivation of the LA disrupted conditioning to the discrete tone CS, but also either impaired or enhanced contextual conditioning, depending on whether the context was in the foreground or in the background. Hence, these findings refine the current model of the amygdala function in emotional learning by showing that the BLA and the LA not only differentially contribute to elemental and context–US association, but also promote, through their interaction, the most relevant of these two associations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1183256Documentos Relacionados
- Basolateral amygdala is not critical for cognitive memory of contextual fear conditioning
- The amygdala is not necessary for unconditioned stimulus inflation after Pavlovian fear conditioning in rats
- Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats
- Differential Fear Conditioning Induces Reciprocal Changes in the Sensory Responses of Lateral Amygdala Neurons to the CS+ and CS−
- Computer-Assisted Behavioral Assessment of Pavlovian Fear Conditioning in Mice