A Cohort Study of Thiazolidinediones and Fractures in Older Adults with Diabetes

AUTOR(ES)

Solomon, Daniel H.

FONTE

The Endocrine Society

RESUMO

Context: Thiazolidenediones (TZDs) are selective ligands of peroxisome-proliferator-activated receptor-γ and have been shown to reduce bone mineral density. Recent results from several randomized controlled trials find an increased risk of fracture with TZDs compared with other oral antidiabetic agents.

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