A clinical, psychophysical, and electroretinographic survey of patients with autosomal dominant retinitis pigmentosa.

AUTOR(ES)

Lyness, A L

RESUMO

We have surveyed 104 patients (44 families) with autosomal dominant retinitis pigmentosa. The range of the survey includes clinical history, ocular examination, documentation of genetic history, Goldmann kinetic perimetry with IV/4 and I/4 white targets, two-colour static perimetry, and scotopic and photopic electroretinography. Comparison of interfamilial and intrafamilial patterns in the static perimetry data strongly suggests there may be at least two genetic subgroups within the disease characterised by the pattern of loss of rod function: in subgroup D (13 patients, 4 families) this is diffuse and severe, while in subgroup R (28 patients, 13 families) it is regional. In both D and R loss of cone function is regional, and in R it coincides with loss of rod function. In D patients the rod electroretinogram is absent; in all but two R cases it is present and usually substantial. All D patients were aware of night blindness before the age of 10, but most R patients not until after the age of 20. Many of the patients could not be classified because their disease was so advanced. The effect of disease duration on visual acuity and visual field area is described for all patients.

Documentos Relacionados

• Autosomal dominant retinitis pigmentosa with apparent incomplete penetrance: a clinical, electrophysiological, psychophysical, and molecular genetic study.
• Rhodopsin mutations in autosomal dominant retinitis pigmentosa.
• Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa.
• Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa.
• Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.