A clinical isolate of transposon Tn5 expressing streptomycin resistance in Escherichia coli.
AUTOR(ES)
Genilloud, O
RESUMO
The central region of transposon Tn5 carries three antibiotic resistance markers: neo, ble, and str. The str gene codes for a phosphotransferase that inactivates streptomycin. This activity is phenotypically expressed in several gram-negative bacteria but not in Escherichia coli. We identified a Tn5 variant in E. coli clinical isolates that express streptomycin resistance. This transposon carries a 6-base-pair deletion within the str gene, near the 3' end. The same kind of mutation had been previously obtained experimentally from Tn5.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=210903Documentos Relacionados
- Control of transposon Tn5 transposition in Escherichia coli.
- Transposon Tn5 encodes streptomycin resistance in nonenteric bacteria.
- Transposon Tn5 specifies streptomycin resistance in Rhizobium spp.
- Polarity of Tn5 insertion mutations in Escherichia coli.
- Bleomycin increases amikacin and streptomycin resistance in Escherichia coli harboring transposon Tn5.
