6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression
AUTOR(ES)
HOU, CHUN, MIAO, YONG, JI, HANG, WANG, SUSHENG, LIANG, GANG, ZHANG, ZHIHUA, HONG, WEIJIN
FONTE
An. Acad. Bras. Ciênc.
DATA DE PUBLICAÇÃO
2017-12
RESUMO
ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.
Documentos Relacionados
- Regulation of MMP2 and MMP9 metalloproteinases by FSH and growth factors in bovine granulosa cells
- Análise imunohistoquímica da perimatriz e de colesteatomas adquiridos com os marcadores CD31, MMP2 e MMP9
- MMP2 and MMP9 are Associated with Apical Periodontitis Progression and Might be Modulated by TLR2 and MyD88
- Análise imunoistoquímica com os marcadores CD31, MMP2 e MMP9 em colesteatomas adquiridos : uma comparação entre pacientes pediátricos e adultos
- Promoting effects of 6-Gingerol on probiotic adhesion to colonic epithelial cells