Articular Cartilage Pathology
Mostrando 1-9 de 9 artigos, teses e dissertações.
-
1. Estudo da osteoartrose em joelhos de cães secundária à ruptura do ligamento cruzado cranial / Study of the osteoarthitis in knees of dogs secondary to cranial cruciate ligament rupture in dogs
INTRODUÇÃO e OBJETIVO: A osteoartrite (OA) embora frequente tem patogênese incerta em humanos. Descrevemos modelo experimental original de OA em cães, analisando em dois tempos diferentes as consequências da Ruptura Espontânea do Ligamento Cruzado Cranial (RLCCr). MÉTODOS: Vinte animais machos com menos de 5 anos ( 20 a 45 Kg) com RLCCr submetidos à
Publicado em: 2009
-
2. Experimental model of temporomandibular joint arthritis induced by zymozan in rats and the study of the role of nitric oxide / Padronização de modelo experimental de artrite na articulação temporomandibular induzida por zymozan em ratos e estudo do papel do óxido nítrico
Temproromandibular disfunction (TMD) is related to a masticatory system disfunction which can include the temporomandibular joint (TMJ), the masticatory muscles and/or other related structures. TMJ inflammatory disorders are one of the major pathology of TMD afecting a great number of patients. Although TMJs inflammation and pain are important cinical entiti
Publicado em: 2006
-
3. Articular cartilage defects of the knee: correlation between magnetic resonance imaging and gross pathology.
Magnetic resonance imaging (MRI) of the knee articular cartilage is possible owing to the contrast provided by different signal intensities of adjacent menisci and subchondral bone. The objective of this study was to determine the accuracy of MRI in quantitatively detecting thinning and focal defects of articular cartilage in vivo. High resolution MRI was pe
-
4. A Review of Articular Cartilage Pathology and the Use of Glucosamine Sulfate
National Athletic Trainers' Association.
-
5. Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in conjunction with a cartilage-specific promoter to target a constitutively active human MMP-13 to the hyaline cartilages and joints of transgenic mice. Postnatal expression o
American Society for Clinical Investigation.
-
6. Structural characteristics of articular cartilage proteoglycan in IgG induced experimental immune synovitis.
The early changes (five weeks) in the structure of newly synthesised and endogenous articular cartilage sulphated proteoglycans were studied in lapine IgG induced experimental immune synovitis. Rabbits with immune synovitis (IS-IgG) were compared with animals with a developed hypersensitivity to IgG (I-IgG) and with non-treated normal weight matched controls
-
7. Enzyme replacement therapy from birth in a feline model of mucopolysaccharidosis type VI.
We report evidence of a dose responsive effect of enzyme replacement therapy in mucopolysaccharidosis type VI cats from birth, at the clinical, biochemical, and histopathological level. Cats treated with weekly, intravenous recombinant human N-acetylgalactosamine-4-sulfatase at 1 and 5 mg/kg, were heavier, more flexible, had greatly reduced or no spinal cord
-
8. Plasmid DNA encoding transforming growth factor-beta1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model.
Transforming growth factor beta is a potent immunomodulator with both pro- and antiinflammatory activities. Based on its immunosuppressive actions, exogenous TGF-beta has been shown to inhibit autoimmune and chronic inflammatory diseases. To further explore the potential therapeutic role of TGF-beta, we administered a plasmid DNA encoding human TGF-beta1 int
-
9. Induction of Host Matrix Metalloproteinases by Borrelia burgdorferi Differs in Human and Murine Lyme Arthritis
Matrix metalloproteinases (MMPs) are induced from host tissues in response to Borrelia burgdorferi. Upregulation of MMPs may play a role in the dissemination of the organism through extracellular matrix tissues, but it can also result in destructive pathology. Although mice are a well-accepted model for Lyme arthritis, there are significant differences compa
American Society for Microbiology.