Articular Cartilage Metabolism
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Protective effects of tumor necrosis factor-α blockade by adalimumab on articular cartilage and subchondral bone in a rat model of osteoarthritis
We aimed to investigate the effects of an anti-tumor necrosis factor-α antibody (ATNF) on cartilage and subchondral bone in a rat model of osteoarthritis. Twenty-four rats were randomly divided into three groups: sham-operated group (n=8); anterior cruciate ligament transection (ACLT)+normal saline (NS) group (n=8); and ACLT+ATNF group (n=8). The rats in th
Braz J Med Biol Res. Publicado em: 31/07/2015
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2. Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro
Tissue engineering encapsulated cells such as chondrocytes in the carrier matrix have been widely used to repair cartilage defects. However, chondrocyte phenotype is easily lost when chondrocytes are expanded in vitro by a process defined as “dedifferentiation”. To ensure successful therapy, an effective pro-chondrogenic agent is necessary to overcome th
Braz J Med Biol Res. Publicado em: 08/07/2014
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3. Biomarcadores do metabolismo da cartilagem e sua relação com as alterações morfológicas, inflamatórias e funcionais: um estudo sobre a lesão condral secundária em joelhos humanos / Biomarkers of cartilage metabolism and its relationship with morphological, inflammatory and functional changes: a study of secondary chondral injury in human knees
A osteoartrite (OA), doença articular degenerativa, é uma das causas mais freqüentes de dor do sistema músculo-esquelético e de incapacidade para o trabalho no Brasil e no mundo. É uma doença crônica, multifatorial, que leva a uma incapacidade funcional progressiva. Pode surgir em decorrência de lesões em estruturas como ligamento cruzado anterior
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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4. Estudo da osteoartrose em joelhos de cães secundária à ruptura do ligamento cruzado cranial / Study of the osteoarthitis in knees of dogs secondary to cranial cruciate ligament rupture in dogs
INTRODUÇÃO e OBJETIVO: A osteoartrite (OA) embora frequente tem patogênese incerta em humanos. Descrevemos modelo experimental original de OA em cães, analisando em dois tempos diferentes as consequências da Ruptura Espontânea do Ligamento Cruzado Cranial (RLCCr). MÉTODOS: Vinte animais machos com menos de 5 anos ( 20 a 45 Kg) com RLCCr submetidos à
Publicado em: 2009
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5. Avaliação do metabolismo celular decorrente da aplicação de força nos condrócitos do côndilo mandibular e do joelho de suínos / Comparison of in vitro desponse to mechanical loading between the porcine mandibular condyle and ankle articular cartilages
Functionally, the mandibular condylar cartilage is similar to the ankle articular cartilage, both provides lubrication to resist friction and offers protection against external mechanical loading. However, the effect of tension loadings on these two articular cartilages remains unclear. The purpose of this study was to evaluate in vitro, the metabolism of th
Publicado em: 2008
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6. Evaluation of the anti-inflammatory effects of the interleukin-1 receptor antagonist protein in equine synovial fluid using flow cytometric techniques / Avaliação dos efeitos antiinflamatórios da proteína antagonista de receptor de interleucina - 1 (IRAP) por citometria de fluxo em líquido sinovial de eqüino
Joint disease in horses, specifically osteoarthritis, is one of the most prevalent and debilitating illnesses affecting equine industry and for this reason continued research and improvements in therapeutics are needed. Osteoarthritis is a degenerative disease that can be triggered by a number of factors and where ultimately all articular tissues are affecte
Publicado em: 2007
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7. Sulphated glycosaminoglycan synthesis in normal and osteoarthrotic hip cartilage.
The in vitro sulphated glycosaminoglycan metabolism and uronate content of human aged and osteoarthrotic hip articular cartilages have been examined. Cartilages were sampled from nonfibrillated weight-bearing areas and cultured in Dulbecco Modified Eagle's medium with 35SO4. Uptake of 35SO4 was corrected for total sulphate concentration and related to uronat
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8. Sulfate Metabolism in Human Chondrocyte Cultures
The depletion of articular cartilage in the afflicted joints is a primary clinical feature of osteoarthritis. This disorder has been linked to a disturbance in the metabolism of the extracellular matrix components of this tissue. The mechanisms involved in the regulation of sulfated proteoglycan metabolism in articular cartilage were therefore studied by mea
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9. Metabolism of human femoral head cartilage in osteoarthrosis and subcapital fracture.
The cell density and incorporation of 35SO4 and 3H-glycine into human articular cartilage from 8 osteoarthrotic and 7 normal (subcapital fracture) femoral heads were studied. It was found that osteoarthrotic cartilage incorporates on a per cell basis about twice as much 35SO4 and 2--5 times as much 3H-glycine as normal cartilage. There was no relationship be
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10. Therapeutic effects on cartilage metabolism in arthritis as measured by release of proteoglycan structures into the synovial fluid.
Proteoglycans are molecules that are degraded and released from the articular cartilage into the synovial fluid early in an arthritic process. Such released proteoglycans were quantified by an enzyme linked immunosorbent assay (ELISA). The proteoglycan content in synovial fluid from patients with various knee joint arthritides was constant in two samples wit
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11. Sulphate Metabolism of Articular Cartilage after Surgical Interference with the Joint
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12. Adaptation of canine femoral head articular cartilage to long distance running exercise in young beagles.
OBJECTIVE--To study the effects of long term (one year), long distance (up to 40 km/day) running on the metabolism of articular cartilage the biosynthesis of proteoglycans was examined by in vitro labelling of anterior (weight bearing) and posterior (less weight bearing) areas of the femoral head from young beagles. METHODS--Total sulphate incorporation rate