Apoptosis And Endothelial Cell
Mostrando 1-12 de 131 artigos, teses e dissertações.
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1. Molecular mechanisms of organ damage in sepsis: an overview
ABSTRACT Sepsis is one of the most common reasons for hospitalization. This condition is characterized by systemic inflammatory response to infection. International definition of sepsis mainly points out a multi-organ dysfunction caused by a deregulated host response to infection. An uncontrolled inflammatory response, often referred to as "cytokine storm",
Braz J Infect Dis. Publicado em: 2020-12
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2. Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis
Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. The purpose of this study was to investigate the protectiv
Braz J Med Biol Res. Publicado em: 14/11/2018
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3. Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy
Abstract Purpose: To determine the effects of propofol and ketamine anesthesia on liver regeneration in rats after partial hepatectomy (PHT). Methods: Male Wistar albino rats were assigned randomly to four groups of 10. Anesthesia was induced and maintained with propofol in groups 1 and 2, and with ketamine in groups 3 and 4. PHT was undertaken in groups 1
Acta Cir. Bras.. Publicado em: 2017-05
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4. Glutamine treatment attenuates hyperglycemia-induced mitochondrial stress and apoptosis in umbilical vein endothelial cells
OBJECTIVE:The aim of this study was to determine the in vitro effect of glutamine and insulin on apoptosis, mitochondrial membrane potential, cell permeability, and inflammatory cytokines in hyperglycemic umbilical vein endothelial cells.MATERIALS AND METHODS:Human umbilical vein endothelial cells were grown and subjected to glutamine and insulin to examine
Clinics. Publicado em: 2015-08
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5. DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The main objectives of this study were to determine whether DNA h
Braz J Med Biol Res. Publicado em: 30/09/2014
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6. Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure
The hepatitis C virus (HCV) encodes approximately 10 different structural and non-structural proteins, including the envelope glycoprotein 2 (E2). HCV proteins, especially the envelope proteins, bind to cell receptors and can damage tissues. Endothelial inflammation is the most important determinant of fibrosis progression and, consequently, cirrhosis. The a
Mem. Inst. Oswaldo Cruz. Publicado em: 09/09/2014
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7. Ox-LDL increases OX40L in endothelial cells through a LOX-1-dependent mechanism
Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for the development of atherosclerosis, and it can stimulate the expression of a variety of inflammatory signals. As a new and highly sensitive inflammation index, OX40L may be a key to understanding the mechanisms that regulate interactions between cells within the vessel wall and inflammatory
Braz J Med Biol Res. Publicado em: 19/09/2013
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8. Histopathological characterization of experimentally induced cutaneous loxoscelism in rabbits inoculated with Loxosceles similis venom
Envenomation by Loxosceles bites is characterized by dermonecrotic and/or systemic features that lead to several clinical signs and symptoms called loxoscelism. Dermonecrotic lesions are preceded by thrombosis of the dermal plexus. Recent studies show that atheromatous plaque is prone to thrombosis due to endothelial cell apoptosis. To the best of our knowle
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 2012
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9. Reduced occurrence of programmed cell death and gliosis in the retinas of juvenile rabbits after shortterm treatment with intravitreous bevacizumab
OBJECTIVE: Bevacizumab has been widely used as a vascular endothelial growth factor antagonist in the treatment of retinal vasoproliferative disorders in adults and, more recently, in infants with retinopathy of prematurity. Recently, it has been proposed that vascular endothelial growth factor acts as a protective factor for neurons and glial cells, particu
Clinics. Publicado em: 2012
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10. Estudo do papel biológico da enzima ácido graxo sintase (FASN) em células endoteliais derivadas dos vasos sanguíneos / Study of the biological role of the enzyme fatty acid synthase (FASN) in endothelial cells derived from blood vessels
Fatty acid synthase (FASN) is the anabolic enzyme with high expression and activity in several human malignancies, which is responsible for the endogenous synthesis of saturated fatty acids and consequently of the phospholipids present in cell membranes. Inhibition of FASN with orlistat (Xenical), an anti-obesity drug, is described as having anti-neoplastic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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11. Nefropatia crônica por ciclosporina : papel do ácido úrico e do sistema renina angiotensina aldosterona como mediadores de disfunção endotelial, inflamação e vasculopatia / Cyclosporine nephropathy : effect of uric acid and the renin angiotensin aldosterone system as mediators of endothelial dysfunction, inflammation vasculopathy
Chronic allograft nephropathy is characterized by stripped tubular atrophy and interstitial fibrosis, in presence of arteriolar hyalinosis, resembling an ischemic pattern of chronic kidney disease. Chronic ischemia is associated with reduced glomerular filtration rate, and increase in serum uric acid levels. Cyclosporine per se also has a direct effect on tu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/08/2011
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12. Papel dos leucócitos na fisiopatologia da anemia falciforme / Role of leukocytes in sickle cell anemia pathophysiology
Sickle Cell Disease (SCD) is a disorder of hemoglobin synthesis, caused by a point mutation, and resulting in the production of abnormal sickle hemoglobin, HbS. The consequence of low oxygen levels is HbS polymerization, which is responsible for the vaso-occlusive phenomenon that is the hallmark of the disease. SCD is a chronic inflammatory disease character
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011