Antiviral Agents Therapeutic Use
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Influência dos polimorfismos no promotor do gene da interleucina-10 na resposta a antivirais em pacientes com hepatite C crônica / Influence of Interleukin 10 gene promoter polymorphisms on the antiviral response of patients with chronic hepatitis C
Na infecção crônica pelo vírus da hepatite C (VHC), a persistência do vírus e a resposta à terapia antiviral tem sido associada com a produção de níveis inadequados de diversas citocinas na resposta imunológica e inflamatória. A interleucina 10 (IL10) é uma potente citocina antiinflamatória e parece ter um papel importante na resposta do hosped
Publicado em: 2008
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2. Protease Inhibitors as Antiviral Agents
Currently, there are a number of approved antiviral agents for use in the treatment of viral infections. However, many instances exist in which the use of a second antiviral agent would be beneficial because it would allow the option of either an alternative or a combination therapeutic approach. Accordingly, virus-encoded proteases have emerged as new targe
American Society for Microbiology.
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3. Hyporeactivity of Infection: Potential Limitation to Therapeutic Use of Interferon-Inducing Agents
Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosi
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4. Efficacy of S26308 against guinea pig cytomegalovirus infection.
Prophylactic use of antiviral agents against cytomegalovirus (CMV) is particularly indicated for the immunocompromised host because morbidity and mortality due to CMV occur most frequently following immunosuppression. We have evaluated the new Riker compound S26308 for its therapeutic and prophylactic antiviral activity against CMV in guinea pigs. The effica
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5. Perspectives on antiviral use during pandemic influenza.
Antiviral agents could potentially play a major role in the initial response to pandemic influenza, particularly with the likelihood that an effective vaccine is unavailable, by reducing morbidity and mortality. The M2 inhibitors are partially effective for chemoprophylaxis of pandemic influenza and evidence from studies of interpandemic influenza indicate t
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6. Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit.
Mimetic peptides capable of selectively disrupting protein-protein interactions represent potential therapeutic agents for inhibition of viral and cellular enzymes. This approach was first suggested by the observation that the peptide YAGAVVNDL, corresponding to the carboxyl-terminal 9 amino acids of the small subunit of ribonucleotide reductase of herpes si
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7. Use of Cotton Rats to Evaluate the Efficacy of Antivirals in Treatment of Measles Virus Infections
No practical animal models for the testing of chemotherapeutic or biologic agents identified in cell culture assays as being active against measles virus (MV) are currently available. Cotton rats may serve this purpose. To evaluate this possibility, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR) and poly(acrylamidomethyl propanesulfonate) (PAM
American Society for Microbiology.
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8. Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation.
The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system. The effect of isoprinosine on in vitro proliferation
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9. Use of a Photodensitometric Technique to Quantify Microscopic Lung Lesions in Mice: Antiviral Activity Against Swine Influenza Virus
During studies of swine influenza virus (A/NJ/76) infection, a technique was devised to quantify the pulmonary lesions in infected mice treated at different time intervals with antiviral chemotherapeutic agents. The technique is based on the premise that as the severity of microscopic change increases, the optical density of lung sections also increases beca
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10. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.
Two aromatic polycyclic diones hypericin and pseudohypericin have potent antiretroviral activity; these substances occur in plants of the Hypericum family. Both compounds are highly effective in preventing viral-induced manifestations that follow infections with a variety of retroviruses in vivo and in vitro. Pseudohypericin and hypericin probably interfere
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11. Comparative toxicities of amphotericin B and its monomethyl ester derivative on glial cells in culture.
Amphotericin B (AmB) is a potent antifungal polyene macrolide antibiotic and is the drug of choice for the treatment of deep-seated mycotic infections. Its use is limited, owing to its nephrotoxicity, and it must be dispersed in deoxycholate for parenteral administration. In contrast, AME (the monomethyl derivative of AmB) is water dispersible, is appreciabl
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12. Unique Anti-Human Immunodeficiency Virus Activities of the Nonnucleoside Reverse Transcriptase Inhibitors Calanolide A, Costatolide, and Dihydrocostatolide
(+)-Calanolide A (NSC 650886) has previously been reported to be a unique and specific nonnucleoside inhibitor of the reverse transcriptase (RT) of human immunodeficiency virus (HIV) type 1 (HIV-1) (M. J. Currens et al., J. Pharmacol. Exp. Ther., 279:645–651, 1996). Two isomers of calanolide A, (−)-calanolide B (NSC 661122; costatolide) and (−)-dihydro
American Society for Microbiology.