Antithrombins
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Marcadores de coagulação intravascular disseminada em pacientes graves internados em unidade de terapia intensiva.
Disseminated intravascular coagulation (DIC) is a syndrome caused by systemic activation of clotting factors and it is frequently associated with several diseases such as sepsis, trauma, shock, cancer, and immune and vascular disorders. Sepsis is the main clinical condition associated to DIC. In some cases, the clinical outcome is very fast and severe, and a
Publicado em: 2007
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2. Impact of the laboratory screening on thrombophilia for the secondary prevention and management of the patients with venous thromboembolism / Impacto da pesquisa laboratorial de trombofilia na prevençao secundaria e orientação dos doentes com troboembolismo venoso
O tromboembolismo venoso (TEV) afeta de 1 a 3 indivíduos por mil habitantes/ano. O conhecimento atual das trombofilias permite a associação com cerca de 40% dos casos de TEV. Há controvérsias quanto ao valor da pesquisa laboratorial de trombofilia para o benefício dos doentes com tromboembolismo venoso. Procuraram-se as variáveis preditivas para a pes
Publicado em: 2006
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3. A method for the differential determination of plasma antithrombins.
A method for the differential determination of plasma antithrombins, antithrombin III and alpha2 macroglobulin, is described. The method is based on the selective inactivation of plasma alpha2 macroglobulin by treatment with 0-1 M methylamine for 10 minutes at 37 degrees C and on the observation that antithrombin III and alpha2 macroglobulin inhibited in def
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4. Pleiotropic effects of antithrombin strand 1C substitution mutations.
Six different substitution mutations were identified in four different amino acid residues of antithrombin strand 1C and the polypeptide leading into strand 4B (F402S, F402C, F402L, A404T, N405K, and P407T), and are responsible for functional antithrombin deficiency in seven independently ascertained kindreds (Rosny, Torino, Maisons-Laffitte, Paris 3, La Roc
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5. The anticoagulant activation of antithrombin by heparin
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases until it binds to the heparan side chains that line the microvasculature. The binding specifically occurs to a core pentasaccharide present both in the heparans and in their therapeutic derivative heparin. The accompanying conformational change of antithrombin
The National Academy of Sciences of the USA.
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6. Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.
Since the antithrombin action of heparin fails to interrupt arterial thrombosis, a mediating role for thrombin (EC 3.4.21.5) in the formation of high-shear platelet-dependent thrombus has been unproven. To determine whether thrombin is important in acute arterial thrombus formation and to assess the therapeutic potential of inhibiting its action, the effects