Antiprotozoal Agents
Mostrando 1-12 de 29 artigos, teses e dissertações.
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1. Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges
Abstract Chagas' disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affect millions of people worldwide. The available drugs for treatment of this infection cause serious side effects and have variable efficacy, especially in the chronic phase of the disease. In this context, natural compounds have shown great potential for the disco
Rev. bras. farmacogn.. Publicado em: 2015-12
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2. New drugs with antiprotozoal activity from marine algae: a review
The use of indigenous or remote popular knowledge to identify new drugs against diseases or infections is a well-known approach in medicine. The inhabitants of coastal regions are known to prepare algae extracts for the treatment of disorders and ailments such as wounds, fever and stomach aches, as for the prevention of arrhythmia. Recent trends in drug rese
Rev. bras. farmacogn.. Publicado em: 2014-06
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3. Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, mainly of those obtained from natural sources. This study aimed to provide an evaluation of the trypanocidal activity of 92 ethanol extrac
Revista Brasileira de Farmacognosia. Publicado em: 24/01/2012
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4. Isolamento, investigação química e avaliação do potencial antibiótico, antibiofilme e anti-trichomonas vaginalis de fungos associados a organismos marinhos da costa sul do Brasil / Isolation, chemical investigation and evaluation of antibiotic, antibiofilm and anti-Trichomonas vaginalisactivities of fungi associated to marine organisms from south brazilian coast
Fungi isolated from marine organisms attract the interest of many researchers around the world, since they produce differentiated secondary metabolites due to the environmental conditions to which these organisms are subjected. Several biological activities have been reported for these compounds, mainly as antitumoral, antibacterial and, antiprotozoal. The i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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5. ENSAIO CLÍNICO RANDOMIZADO DA NITAZOXANIDA NO TRATAMENTO DE POLIPARASITOSES INTESTINAIS EM MUNICÍPIOS DA ZONA DA MATA, MINAS GERAIS / Random clinical test of the nitazoxanide in the treatment of intestinal poliparasitism in cities in Zona da Mata, Minas Gerais
As parasitoses intestinais são um importante problema de saúde pública principalmente nos países subdesenvolvidos ou em desenvolvimento. Embora o parasitismo intestinal seja amplamente reconhecido como relevante no contexto epidemiológico de diversas comunidades, os estudos sobre o assunto são ainda insuficientes, principalmente no Brasil. Em vista da
Publicado em: 2009
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6. AvaliaÃÃo da eficÃcia terapÃutica da Mentha crispa no tratamento da giardÃase. / Evaluation of the therapeutical effectiveness of mentha crispa in the treatment of the giardÃase
A infecÃÃo por Giardia lamblia à endÃmica em vÃrias partes do mundo. Estima-se que em torno de 200 milhÃes de pessoas sÃo parasitadas anualmente, sendo a doenÃa uma importante causa de morbidade em todo o mundo. O tratamento atual da giardÃase compreende o uso de vÃrios fÃrmacos. FitoterÃpicos formulados com Mentha crispa tambÃm tÃm sido empreg
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/11/2008
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7. SÃntese e avaliaÃÃo de atividades Anti-Toxoplama gondii e antimicrobiana de Tiossemicarbazidas, 4-Tiazolidinonas e 1,3,4-TiadiazÃis obidos a partir do Ãster 5-Metil-1H-Imidazol-4-Carboxilato de Etila
Toxoplasmosis is an infection caused by Toxoplasma gondii, a protozoan parasite with very complex biology and wide distribution in several geographical areas of the globe. In 2005, our research group published a paper reporting an exceptional anti-T. gondii activity for thiosemicarbazones and arylhydrazono-4-thiazolidinones, with a nitro group in aryl moiety
Publicado em: 2007
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8. Trypanosoma cruzi: inquiry on essential oils as potential trypanocidals agents. / Trypanosoma cruzi: investigação sobre óleos essenciais como potenciais agentes tripanocidas.
Nifurtimox e benznidazol, as drogas usadas no tratamento da doença de Chagas, apresentam vários efeitos colaterais e tem sua eficácia limitada, especialmente na fase crônica. Diversos produtos naturais têm demonstrado potencial antiparasitário em laboratório e, nesse sentido, compostos obtidos de plantas aparecem como agentes potenciais para o desenvo
Publicado em: 2007
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9. Antileishmanial and trypanocidal activity of Brazilian Cerrado plants
The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishman
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-11
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10. "Estudo químico e atividades biológicas de extratos obtidos de culturas de Penicillium verrucosum Dierck" / Chemical study and biological activities of crude extracts obtained from different cultures of Penicillium verrucosum Dierck
The absence of an effective treatment for Chagas disease and Leishmaniasis stimulates the search for new active compounds. The enzymes GAPDH from T. cruzi and APRT from L. tarentolae are attractive targets for rational search of antiprotozoal agents, taking part in essential pathways of the pathogens. Natural products are rich in structural diversity and b
Publicado em: 2003
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11. Human antiprotozoal therapy: past, present, and future.
Human protozoal infections are ubiquitous and occur worldwide. In many cases, antiprotozoal agents currently in use predate the modern antibiotic era. Despite the relative lag in development of new antiprotozoal agents, the 1990s have witnessed an increasing level of interest in these infections, inspired by international travel and immigration, a growing aw
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12. Analogs of 5-methylthioribose, a novel class of antiprotozoal agents.
Since drug resistance and toxicity limit the use of available antiprotozoal agents, it is important that new drugs be developed as soon as possible. In this study, the method by which several protozoa degrade 5'-methylthioadenosine (MTA) was shown to differ from MTA catabolism in human cells. To exploit this metabolic difference, two analogs of methylthiorib