Antioxidants Defenses
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Oxidative stress: therapeutic approaches for cervical cancer treatment
OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory
Clinics. Publicado em: 10/12/2018
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2. Efeito do tratamento com estradiol sobre o controle da pressão arterial e o estresse oxidativo
In this thesis was studied the sympathovagal and the nitric oxide (NO)/reactive oxygen species (ROS) balances in ovariectomized female rats. It was verified the effectiveness of 17b-estradiol in the blood pressure (BP) control and cardiovascular oxidative stress using low doses of estrogen. Then, we developed three protocols to evaluate morphometric, hemodyn
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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3. AVALIAÇÃO DA ATIVIDADE DE ENZIMAS QUE DEGRADAM NUCLEOTÍDEOS DE ADENINA E ÉSTERES DE COLINA E ESTUDO DO PERFIL OXIDATIVO EM PACIENTES COM CARDIOPATIA ISQUÊMICA / EVALUATION OF THE ENZYME ACTIVITY THAT DEGRADES ADENINE NUCLEOTIDES AND ESTERS OF CHOLINE AND STUDY OF OXIDATIVE PROFILE IN PATIENTS WITH ISCHEMIC HEART
Ischemic heart disease (IHD) is a major cardiovascular disease. The term ischemiarefers to a lack of oxygen due to inadequate perfusion, which results from an imbalance between oxygen supply and demand. The most common cause of myocardial ischemia is atherosclerotic obstructive coronary artery disease caused by rupture or ulceration of atheromatous plaque an
Publicado em: 2010
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4. AVALIAÇÃO DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA d-AMINOLEVULINATO DESIDRATASE EM PACIENTES TRANSPLANTADOS DE MEDULA ÓSSEA / EVALUATION OF OXIDATIVE STRESS AND d-AMINOLEVULINIC ACID DEHYDRATASE IN BONE MARROW TRANSPLANTATION PATIENTS
Bone marrow transplantation (BMT) has been used in the treatment of a number of diseases. Before BMT, patients are submitted to a conditioning regime (CR) that consists of administration of high doses of chemo- or radiotherapy. This CR has the objective of eradicating the residual disease and inducing an immunosuppression that will allow the engraftment of c
Publicado em: 2008
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5. Indicadores Biológicos de Exposição a solventes orgânicos e sua inter-relação com o estresse oxidativo / Biological Exposure Indices of organic solvents and its relationship with the oxidative stress
The use of organic solvents in the work environment represents a significant risk to workers health. The painters composed, among others, a group of individuals who are in direct contact with solvents through the respiratory and dermal route. The biological monitoring, through biological exposure index (BEI) determination, can ensure the emergence of chronic
Publicado em: 2008
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6. Influence of serum bilirubin levels on the occurrence and course of neonatal sepsis in preterm infants younger than 36 gestational age weeks / Influência dos níveis séricos de bilirrubina sobre a ocorrência e a evolução da sepse neonatal em recém-nascidos pré-termo com idade gestacional menor que 36 semanas
INTRODUCTION: several components of the antioxidative defenses are deficient in the newborn. Bilirubin is a potent antioxidant and can counterbalance the deficiency of those components. This antioxidant action is potencialized by biliverdin reductase. The present study aimed at identifying the protective effect of bilirubin on neonatal sepsis in premature ba
Publicado em: 2007
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7. OXIDATIVE STRESS IN HEMODIALIZED PATIENTS AND THE INFLUENCE OF TERAPEUTIC TREATMENT / O ESTRESSE OXIDATIVO EM PACIENTES HEMODIALISADOS E A INFLUÊNCIA DO TRATAMENTO TERAPÊUTICO
The imbalance between the oxidant species formation and the activity of antioxidants is known as oxidative stress and it is directly related to the etiology and/or the progression of chronic diseases such as chronic renal failure (CRF), atherosclerosis and cardiovascular diseases. The CRF can be the result of variety renal injuries that lead to toxic substan
Publicado em: 2006
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8. Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice
Chemoprotection by dietary agents is a promising strategy for cancer prevention. The aim of the present study was to evaluate the combined effect of tomato and garlic against 7,12-dimethylbenz- [a]anthracene (DMBA)-induced genetic damage and oxidative stress in 12-14-week-old male Swiss albino mice. The animals were randomized into experimental and control g
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-07
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9. Implicações toxicologicas e bioquimicas de xenobioticos em Curimbata (Prochilodus scrofa, Steindachnner, 1881) um peixe tropical brasileiro
Cytochromes P450 constitute a superfamily of hemeproteins that play a vital role in the metabolism of a wide variety of compounds such as steroids, fatty acids, drugs and environmental pollutants. Xenobiotic metabolism and role of cytochrome P450 are important areas of molecular pharmacology and toxicology, and of great interest mainly in the studies on prev
Publicado em: 2002
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10. Influence of season and pollution on the antioxidant defenses of the cichlid fish acará (Geophagus brasiliensis)
The livers of Geophagus brasiliensis collected from both a non-polluted site and a polluted site were analyzed for different antioxidant defenses, O2 consumption, thiobarbituric acid-reactive substance (TBARS) levels, and histological damage. Compared to controls (116.6 ± 26.1 nmol g-1), TBARS levels were enhanced at the polluted site (284.2 ± 25.6 nmol g-
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-06
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11. Hyperoxia and prolongation of aminoglycoside-induced postantibiotic effect in Pseudomonas aeruginosa: role of reactive oxygen species.
Hyperoxia prolongs the postantibiotic effect (PAE) of the aminoglycoside tobramycin in Pseudomonas aeruginosa. We tested the hypothesis that the PAE is prolonged because hyperoxia increases free radical flux while tobramycin inhibits the induction of antioxidant defenses. Exposure of P. aeruginosa to hyperoxia (100% O2) for 1 h increased superoxide dismutase
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12. A crucial role for thiol antioxidants in estrogen-deficiency bone loss
The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere, estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS stimulate osteoclasts, the cells that resorb bone. Thus, estrogen might prevent bone loss by enhancing oxidant defenses in bone. We found that glutathione and thioredoxin, the major thiol a
American Society for Clinical Investigation.