Antimicrobial Residue
Mostrando 13-24 de 69 artigos, teses e dissertações.
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13. Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos / Structural studies of Histatin-5 and its analogue, TOAC0-Histatin-5: interaction with metals and biomimetic systems
The mechanism of action of histatin-5 (Hst-5), an antifungal antimicrobial peptide from human saliva is not completely clarified. Circular dichroism (CD), fluorescence, and electron paramagnetic resonance (EPR) were used to examine the conformational behavior of Hst-5 and its analogue containing the paramagnetic amino acid TOAC at the N-terminus (TOAC0-Hst-5
Publicado em: 2008
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14. Fatores fisiológicos, clínicos e farmacológicos, determinantes de resíduos de antimicrobiano no leite, avaliados em protocolos terapêuticos de mastite em bovinos leiteiros / Evaluation of some physiological, clinical and pharmacological factors to antimicrobials residues in milk under different management and therapeutic protocols
Atualmente a terapia e as práticas de manejo da mastite estão baseadas na administração de agentes antimicrobianos com ampla atividade contra os microrganismos mais comuns desta doença. Os fármacos são administrados diretamente no canal da teta e/ou por sistêmica. Os tratamentos com antimicrobianos são realizados durante o período seco como terapia
Publicado em: 2006
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15. Farmacocinetica e determinação de residuos de enrofloxacina e seu metabolito em tecidos de frangos
Enrofloxacin (EFX) is a synthetic fluoroquinolone antimicrobial agent widely employed in veterinary medicine, particularly in poultry. Its major metabolite is ciprofloxacin (CFX). The HPLC analyses were carried out using a cationic-octadecil mixed column and a 0.05 mol L (pH 2.5) phosphate buffer/ACN as mobile phase, with a linear elution gradient and a flow
Publicado em: 2004
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16. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.
Immune challenge to the insect Podisus maculiventris induces synthesis of a 21-residue peptide with sequence homology to frog skin antimicrobial peptides of the brevinin family. The insect and frog peptides have in common a C-terminally located disulfide bridge delineating a cationic loop. The peptide is bactericidal and fungicidal, exhibiting the largest an
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17. De Novo Generation of Cationic Antimicrobial Peptides: Influence of Length and Tryptophan Substitution on Antimicrobial Activity
Comparison of human immunodeficiency virus lentiviral lytic peptide 1 with other host-derived peptides indicates that antimicrobial properties of membrane-active peptides are markedly influenced by their cationic, hydrophobic, and amphipathic properties. Many common themes, such as Arg composition of the cationic face of an amphipathic helix and the importan
American Society for Microbiology.
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18. Improved Derivatives of Bactenecin, a Cyclic Dodecameric Antimicrobial Cationic Peptide
Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram-positive
American Society for Microbiology.
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19. The antimicrobial effect of a structural variant of subtilin against outgrowing Bacillus cereus T spores and vegetative cells occurs by different mechanisms.
Subtilin is a ribosomally synthesized antimicrobial peptide that contains several unusual amino acids as a result of posttranslational modifications. Site-directed mutagenesis was employed to construct a structural variant of subtilin in which the unusual dehydroalanine (Dha) residue at position 5 was changed to alanine. Proton nuclear magnetic resonance spe
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20. Characterization of a Fish Antimicrobial Peptide: Gene Expression, Subcellular Localization, and Spectrum of Activity†
Antimicrobial peptides are proposed to act as the first line of mucosal host defense by exerting broad-spectrum microbicidal activity against pathogenic microbes. Pleurocidin, a new 25-residue linear antimicrobial peptide, was recently isolated from the skin secretions of winter flounder (Pleuronectes americanus). The present study identifies the cDNA and ge
American Society for Microbiology.
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21. Subinhibitory Concentrations of the Deformylase Inhibitor Actinonin Increase Bacterial Release of Neutrophil-Activating Peptides: a New Approach to Antimicrobial Chemotherapy
Bacterial protein synthesis starts with a formylated methionine residue, and this residue is sequentially cleaved away by a unique peptide deformylase (PDF) and a methionine aminopeptidase to generate mature proteins. The formylation-deformylation of proteins is a unique hallmark of bacterial metabolism and has recently become an attractive target for the de
American Society for Microbiology.
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22. Platelet Microbicidal Protein 1: Structural Themes of a Multifunctional Antimicrobial Peptide
Mammalian platelets release platelet microbicidal proteins (PMPs) as components of their antimicrobial armamentarium. The present studies defined the structure of PMP-1 and examined its structure-activity relationships. Amino acid sequencing and mass spectroscopy demonstrated that distinct N-terminal polymorphism variants of PMP-1 isolated from nonstimulated
American Society for Microbiology.
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23. APD: the Antimicrobial Peptide Database
An antimicrobial peptide database (APD) has been established based on an extensive literature search. It contains detailed information for 525 peptides (498 antibacterial, 155 antifungal, 28 antiviral and 18 antitumor). APD provides interactive interfaces for peptide query, prediction and design. It also provides statistical data for a select group of or all
Oxford University Press.
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24. The Drosophila Toll-9 activates a constitutive antimicrobial defense
The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1. Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the
Oxford University Press.