Antigenotoxic Effect
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract
Abstract: Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic extract from H. courbaril seeds. Therefore, for the cytotoxicity test an anti-melanom
An. Acad. Bras. Ciênc.. Publicado em: 02/12/2019
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2. Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin
Abstract Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of new products that are more selective and effective and have fewer side effects. Accordingly, a novel ester was synthesized that contains two pharmacophores with important biological activities:
Genet. Mol. Biol.. Publicado em: 27/06/2019
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3. In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems
ABSTRACT Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and a
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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4. Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system
Abstract Brazilian green propolis is a resinous substance prepared by bees from parts of the plant Baccharis dracunculifolia. As it possess several biological properties, this work assessed the cytotoxic/anticytotoxic, genotoxic/antigenotoxic and mutagenic/antimutagenic potential of ethanolic extracts of Brazilian green propolis (EEGP) and of B. dracunculifo
Genet. Mol. Biol.. Publicado em: 24/05/2016
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5. Protective effects of acerola juice on genotoxicity induced by iron in vivo
Abstract Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its h
Genet. Mol. Biol.. Publicado em: 2016-03
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6. Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá
Abstract The species Maytenus guyanensis Klotzsch ex Reissek, Celastraceae, present a wide variety of possible pharmacological activities and its roots and stems are used by popular medicine in the western Amazon rainforest. Few studies have demonstrated the genotoxic safety of the popular use of this species, and owing to this, the present study aimed to pe
Rev. bras. farmacogn.. Publicado em: 2015-04
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7. In vivo evaluation of the antimutagenic and antigenotoxic effects of β-glucan extracted from Saccharomyces cerevisiae in acute treatment with multiple doses
Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and antigenotoxic activity of β-glucan. We set
Genet. Mol. Biol.. Publicado em: 19/07/2013
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8. Investigation of protective effects of Erythrina velutina extract against MMS induced damages in the root meristem cells of Allium cepa
Erythrina velutina Willd., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutina has been known to present analgesic, anti-inflammatory and antibacterial activities, however, it is unknown if thi
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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9. Atividade antioxidante de extratos e compostos isolados de Eugenia umbelliflora e Rapanea ferrugínea / ANTIOXIDANT ACTIVITY OF ISOLATED COMPOUNDS AND EXTRACTS OF Eugenia umbelliflora and Rapanea ferruginea
Eugenia umbeliflora is popularly known as baguaçu, guapê or guaramirim in Portuguese and Brazilian Cherry in English. This species is used in popular medicine to treat diseases such as arthritis, rheumatism and diabetes, although there have been few biological studies to verify the effectiveness of these extracts. Rapanea ferruginea is popularly known as c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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10. The antigenotoxic activity of latex from Himatanthus articulatus
Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a native plant to the Amazon popularly used to treat ulcers, tumors, inflammations, cancer, syphilis and malaria. The aim of the present study was to investigate the in vivo genotoxic/antigenotoxic and mutagenic potential of this plant, using the comet and the micronucleus assays in mice. Female and mal
Revista Brasileira de Farmacognosia. Publicado em: 29/11/2011
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11. Chemical composition and antigenotoxic properties of Lippia alba essential oils
The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-β-
Genetics and Molecular Biology. Publicado em: 29/07/2011
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12. Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice
Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as "erva-cidreira" or "melissa", it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigat
Genetics and Molecular Biology. Publicado em: 2011