Antigenic Mutation
Mostrando 1-12 de 119 artigos, teses e dissertações.
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1. Uma aplicação da abordagem de Verhulst para investigar a influência da mutação antigênica na durabilidade da memória imune.
Modelos matemáticos têm sido utilizados para responder a várias questões imunológicas complexas como o processo de memória imunológica e a duração de vacinas, onde os mecanismos de regulação ainda não são suficientemente conhecidos. Neste artigo é apresentada uma abordagem in silico para simular o processo de mutação antigênica e suas implic
Campinas: Embrapa Informática Agropecuária. Publicado em: 2011
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2. Um modelo computacional para estudar a influência dos anticorpos na manutenção da memória imunológica.
Este artigo apresenta um modelo computacional para estudar a evolução temporal do repertório clonal, incluindo populações de anticorpos. O modelo proposto também foi utilizado para estudar o comportamento da memória imunológica quando populações antigênicas são inoculadas aleatoriamente para simular um processo de mutação viral. Os resultados d
Campinas: Embrapa Informática Agropecuária. Publicado em: 2011
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3. Estudos de expressão do HBsAg: hepatite B oculta, genótipos do HBV e quimeras de HBV e HCV. / Studies of expression of the HBsAg: occult hepatitis B, genotypes of the HBV and chimeras of HBV and HCV.
Introduction: Hepatitis B virus (HBV) is classified into eight genotypes (A-H) that have a distinct distribution in different geographical regions. In Brazil, genotypes A, D and F are the most prevalent. HBV infection is commonly diagnosed by the presence of the surface antigen (HBsAg) in serum. Amino acid mutations may affect HBsAg secretion levels, as well
Publicado em: 2008
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4. Epidemiologia molecular dos vírus dengue em Goiânia-GO, 1994 - 2006: vigilância laboratorial e caracterização dos sorotipos circulares / Molecular epidemiology of dengue virus in Goiânia, 1994-2006: laboratorial surveillance and characterization of circulate serotypes
Nowadays, dengue constitute the major public health problem, because is relevant cause of illness and death between thousands people that resident in the tropical and subtropical regions in world. The dengue virus is classified as four serotypes (DENV-1, 2, 3 and 4) according to antigenic differences and characterized intra-typical groups called genotypes. T
Publicado em: 2008
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5. Mutation and Recombination in the Upstream Homology Box-Flanked ospE-Related Genes of the Lyme Disease Spirochetes Result in the Development of New Antigenic Variants during Infection
The ospE gene family of the Lyme disease spirochetes encodes a polymorphic group of immunogenic lipoproteins. The ospE genes are one of several gene families that are flanked by a highly conserved upstream sequence called the upstream homology box, or UHB, element. Earlier analyses in our lab demonstrated that ospE-related genes are characterized by defined
American Society for Microbiology.
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6. Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele.
Mutagen treatment of P815 tumour cells produces tum- variants that are rejected by syngeneic mice because they express new transplantation antigens. These 'tum-' antigens elicit a cytolytic T lymphocyte (CTL) response but no detectable antibody response. The DNA of tum- variant P35 was transfected into P815 cell line P1.HTR. Transfectants expressing tum- ant
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7. Rapid antigenic-type replacement and DNA sequence evolution of canine parvovirus.
Analysis of canine parvovirus (CPV) isolates with a panel of monoclonal antibodies showed that after 1986, most viruses isolated from dogs in many parts of the United States differed antigenically from the viruses isolated prior to that date. The new antigenic type (designated CPV type 2b) has largely replaced the previous antigenic type (CPV type 2a) among
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8. Physical mapping of the mutation in an antigenic variant of herpes simplex virus type 1 by use of an immunoreactive plaque assay.
Two mutations affecting herpes simplex virus type 1 glycoprotein B were mapped by marker rescue using cloned sequences of wild-type herpes simplex virus type 1 strain KOS DNA. One mutant, tsB5, is a temperature-sensitive mutant which does not express mature, functional glycoprotein B at the nonpermissive temperature. The other mutant, marB1.1, expresses an a
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9. A Canine Parvovirus Mutant Is Spreading in Italy
By antigenic and genetic characterization of canine parvovirus type 2 (CPV-2) strains collected in 2001 and 2002 in Italy, it was possible to observe the spread of viruses with an unusual mutation, Glu-426, affecting a major antigenic epitope of CPV-2. Out of 67 strains analyzed, 49 (73.13%) were characterized as CPV-2a, 6 (8.95%) were characterized as CPV-2
American Society for Microbiology.
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10. The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin.
In 1982 we characterized the antigenic sites of the haemagglutinin of influenza A/PR/8/34, which is an influenza strain of the H1 subtype that was isolated from humans in 1934, by studying mutants which escaped neutralization by antibody. Four antigenic sites, namely Cb, Sa, Sb and Ca, were found to be located near the tip of the trimeric haemagglutinin spik
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11. Antigenic structure of envelope glycoprotein E1 of hog cholera virus.
Envelope glycoprotein E1 (gp51 to gp54) is the most antigenic protein of hog cholera virus or classical swine fever virus (CSFV). Four antigenic domains, A to D, have been mapped on E1 with a panel of monoclonal antibodies (MAbs) raised against CSFV strain Brescia. The boundaries of these domains have been established by extensive studies on binding of MAbs
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12. Evidence that bacteriophage T4 eph1 is a missense hoc mutation.
An electrophoretic mutation of bacteriophage T4, eph1, appears to code for a missense hoc (highly antigenic outer capsid) protein. This is based on the observation that particles lacking hoc protein (hoc- particles), after incubation in a crude extract of Escherichia coli infected with phage carrying the eph1 mutation acquired the electrophoretic mobility of