Anticonvulsive Drug
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
ABSTRACT Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders.
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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2. Antinociceptive behavioral and regenerative study with gabapentin treatment in a model of experimental neuropathic pains / Estudo dos efeitos antinociceptivos, comportamentais e regenerativos do tratamento com gabapentina em modelo experimental de dor neuropÃtica.
A dor neuropÃtica possui mecanismos de difÃcil compreensÃo que se modificam com a sua evoluÃÃo dificultando a terapÃutica. O modelo por constriÃÃo crÃnica do nervo ciÃtico (CCNC) simula esta condiÃÃo. A gabapentina (GBP) Ã um anticonvulsivo muito utilizado como analgÃsico na dor neuropÃtica e existem poucos relatos sobre seus efeitos na ativid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/11/2009
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3. Effect of vigabatrin (gamma-vinyl GABA) on amino acid levels in CSF of epileptic patients.
Vigabatrin (gamma-vinyl GABA) is a new anticonvulsive drug that irreversibly inhibits the activity of GABA transaminase. The effect of vigabatrin on neurotransmission-related amino acids in CSF of 28 epileptic patients was studied and the relationship between the amino acid pattern and clinical response during 7 months of administration of vigabatrin. Of thi
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4. Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment
Chronic restraint stress, psychosocial stress, as well as systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in the rat hippocampus, in which adrenal steroids and excitatory amino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hippocampus. This stress-ind
National Academy of Sciences.