Anticonvulsant Effect
Mostrando 1-12 de 59 artigos, teses e dissertações.
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1. The Effect of Neuromodulatory Drugs on the Intensity of Chronic Pelvic Pain in Women: A Systematic Review
Resumo Objetivo: Avaliar o efeito de drogas neuromoduladoras na intensidade da dor pélvica crônica em mulheres. Fontes de dados: As buscas foram realizadas nas bases de dados PubMed, Cochrane Central, Embase, Lilacs, OpenGrey e Clinical Trials. Seleção dos estudos: As buscas foram realizadas por dois dos autores, não delimitando data de publicação
Revista Brasileira de Ginecologia e Obstetrícia. Publicado em: 2022
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2. Anticonvulsant mechanism of saponins fraction from adventitious roots of Ficus religiosa: possible modulation of GABAergic, calcium and sodium channel functions
ABSTRACT In our previous studies, quantified saponins-rich fraction from adventitious root extract of Ficus religiosa L., Moraceae, showed anticonvulsant effect in acute, as well as chronic mice models of epilepsy. The present study was designed to reveal putative anticonvulsant mechanism of quantified saponins-rich fraction using target specific animal mode
Rev. bras. farmacogn.. Publicado em: 2016-10
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3. Montelukast reduces seizures in pentylenetetrazol-kindled mice
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast,
Braz J Med Biol Res. Publicado em: 23/02/2016
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4. Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves
Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present s
Braz J Med Biol Res. Publicado em: 30/06/2015
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5. Avaliação da atividade neuroprotetora da Parawixina 11 isolada da peçonha da aranha Parawixia bistriata (Araneae, Araneidae), em ratos Wistar submetidos a um modelo de glaucoma agudo / Neuroprotective activity analysis of Parawixin 11, isolated from Parawixia bistriata (Araneae, Araneidae) spider venom, in Wistar rats submitted to an model of acute glaucoma
Glaucoma is defined as a typical optic neuropathy characterized by ganglion cells loss and consequent optic nerve damage, resulting in a gradual reduction of the visual field and eventual blindness. In regard to compounds present in spider venoms, they represent an interesting source of bioactive molecules and the study about the possible neuroprotective eff
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
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6. Tratamento com topiramato melhora a sensibilidade hipotalâmica à insulina em camundongos obesos / Topiramate improves insulin sigmalling the hypothalamus of mice on high-fat diet
Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a frequently side effect reported in patients and animal models treated with TPM. In animal models topiramate may increase levels of hypothalamic corticotropic-releasing hormone (CRH), which is an anorexigenic neuropeptide and may decreas
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/11/2011
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7. Evaluation of effects of dichloromethane fraction from Platonia insignis on pilocarpine-induced seizures
The objective of present study was to evaluate the antioxidant and anticonvulsant activities of dichloromethane fraction (DMF) from Platonia insignis Mart., Clusiaceae. The DMF from P. insignis (2 mg/kg) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor and anticonvulsant activiti
Revista Brasileira de Farmacognosia. Publicado em: 09/09/2011
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8. Bioassay-guided evaluation of central nervous system effects of citronellal in rodents
The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaini
Revista Brasileira de Farmacognosia. Publicado em: 08/07/2011
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9. Evaluation of central nervous system effects of Citrus limon essential oil in mice
The central nervous system (CNS) depressant and anticonvulsant activities of Citrus limon (L.) Osbeck, Rutaceae, essential oil (EO) were investigated in animal models. The EO (50, 100 and 150 mg/kg) injected by oral route (p.o.) in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to thirty days afte
Revista Brasileira de Farmacognosia. Publicado em: 20/05/2011
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10. Antioxidant mechanisms of iso-6-cassine in suppressing seizures induced by pilocarpine
The aim of this study was to evaluate the in vitro antioxidant effects of 12-[(2R,5R,6R)-5-hydroxy-6-methylpiperidin-2-yl]dodecan-2-one (iso-6-cassine; ISO) and the anticonvulsant effects of ISO on pilocarpine-induced seizures in rats. Wistar rats were treated with 0.9% saline (i.p., control group), pilocarpine (400 mg/kg, i.p., pilocarpine group), and the a
Revista Brasileira de Farmacognosia. Publicado em: 25/03/2011
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11. ATIVIDADE ANTICONVULSIVANTE DO ÓLEO DE PEIXE / ANTICONVULSANT ACTIVITY OF FISH OIL
Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigates whether the chronic treatment with fish oil or with olei
Publicado em: 2010
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12. Study of antinociceptive and antiinflammatory monoterpene a,b-epoxy-carvone and its effect on glutamatergic neurotransmission. / Estudo da atividade antinociceptiva e anti-inflamatória do monoterpeno a,b-Epoxi-carvona e seu efeito sobre a neurotransmissão glutamatérgica
The a, b-epoxy-carvone (EC) monoterpene is found in many essential oils from plants, but can also be obtained through organic synthesis from the R-(-)-carvone. Previous studies have demonstrated that this compound exerts depressant effect on central nervous system (CNS), and is also known to have anticonvulsant effects, antioxidant and antimicrobial activiti
Publicado em: 2010