Antiangiogenic Drugs Toxicity
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Bevacizumab INTRA-VITREOUS: ANALYSIS OF RETINAL TOXICITY AFTER 3 MONTHS IN EYES OF RABBITS NOT ALBINO / BEVACIZUMABE INTRA-VÍTREO: ANÁLISE DA TOXICIDADE RETINIANA APÓS 3 MESES EM OLHOS DE COELHOS NÃO ALBINOS
Antiangiogenesis therapy has become a first-line treatment for neovascular age-related macular degeneration (AMD). Bevacizumab has proven to be efficient and cost effective, however its use in AMD is still off-label. PURPOSES: Evaluating the histological toxicity of bevacizumab on the neurosensorial retina (NSR) and the retinal pigmented epithelium (RPE) in
Publicado em: 2009
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2. BEVACIZUMABE INTRA-VÍTREO: ANÁLISE DA TOXICIDADE RETINIANA APÓS 3 MESES EM OLHOS DE COELHOS NÃO ALBINOS / Bevacizumab INTRA-VITREOUS: ANALYSIS OF RETINAL TOXICITY AFTER 3 MONTHS IN EYES OF RABBITS NOT ALBINO
A terapia anti-angiogênica tornou-se o tratamento de primeira linha para a forma neovascular da degeneração macular relacionada à idade. O Bevacizumabe é uma droga com boa eficácia e custo-efetividade, porém seu uso nesta doença ainda é considerado off-label. OBJETIVOS: Avaliar a toxicidade sobre a retina neurossensorial (RNS) e epitélio pigmentado
Publicado em: 2009
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3. Antibody drug-conjugates targeting the tumor vasculature: Current and future developments
Reducing the blood supply of tumors is one modality to combat cancer. Monoclonal antibodies are now established as a key therapeutic approach for a range of diseases. Owing to the ability of antibodies to selectively target endothelial cells within the tumor vasculature, vascular targeting programs have become a mainstay in oncology drug development. However
Landes Bioscience.
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4. A role for survivin in chemoresistance of endothelial cells mediated by VEGF
Although standard anticancer chemotherapeutic drugs have been designed to inhibit the survival or growth of rapidly dividing tumor cells, it is possible to enhance the efficacy of such drugs by targeting the proliferating host endothelial cells (ECs) of the tumor vasculature. A theoretical advantage of this strategy lies in the possibility of circumventing,
The National Academy of Sciences.