Anthracycline
Mostrando 1-12 de 75 artigos, teses e dissertações.
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1. Current treatment preferences in acute myeloid leukemia: a survey in Brazil
ABSTRACT Introduction:: Most adults with acute myeloid leukemia (AML) will eventually relapse from their disease. The combination of 7-day cytarabine and an anthracycline on days 1-3 (the so called “7 + 3” regimen) can be considered standard of care of younger patients with AML. However, the treatment of the elderly ineligible for intensive chemotherapy
Hematol., Transfus. Cell Ther.. Publicado em: 2020-09
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2. Auditory stimulation and cardiac autonomic regulation
Previous studies have already demonstrated that auditory stimulation with music influences the cardiovascular system. In this study, we described the relationship between musical auditory stimulation and heart rate variability. Searches were performed with the Medline, SciELO, Lilacs and Cochrane databases using the following keywords: "auditory stimulation"
Clinics. Publicado em: 2012-08
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3. Padrões de expressão de GRP78 em mulheres com câncer de mama tratadas com antracíclicos / Patterns of GRP78 expression in breast cancer treated with adjuvant anthracycline-based chemotherapy
Introdução: Evidências pré-clínicas implicam GRP78 como um possível marcador de resistência em quimioterapia baseada em antracíclicos em câncer de mama. Objetivos: O presente estudo avalia a relação entre a expressão de GRP78 no retículo endoplasmático (RE) e na membrana celular (MC) e a sobrevida global (SG) e a sobrevida livre de progressão
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2010
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4. Infuência de diferentes limitações nutricionais sobre a produção de retamicina por Streptomyces olindensis ICB20. / Influence of different nutrient limitation on retamycin production by Streptomyces olindesis ICB 20.
O objetivo do presente trabalho foi estudar o efeito de diferentes limitações nutricionais sobre a produção de retamicina por Streptomyces olindensis ICB20. Realizaram-se cultivos contínuos empregando meios limitados em carbono, nitrogênio ou fosfato, variando-se a vazão específica de alimentação entre 0,025 e 0,075 h -1 . A análise dos dados dos
Publicado em: 2006
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5. The secondary alcohol and aglycone metabolites of doxorubicin alter metabolism of human erythrocytes
Anthracyclines, a class of antitumor drugs widely used for the treatment of solid and hematological malignancies, cause a cumulative dose-dependent cardiac toxicity whose biochemical basis is unclear. Recent studies of the role of the metabolites of anthracyclines, i.e., the alcohol metabolite doxorubicinol and aglycone metabolites, have suggested new hypoth
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-12
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6. Anthracycline production by Streptomyces capoamus in batch fermentation
As antraciclinas têm sido estudadas intensamente devido à importância destas como agentes anticancerígenos. Neste trabalho, foi investigada a produção de ciclamicina, um complexo antitumoral da classe das antraciclinas, produzido por Streptomyces capoamus. O meio de fermentação consistiu de glicose, como principal fonte de carbono, e leite de soja, c
Brazilian Archives of Biology and Technology. Publicado em: 2003-06
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7. Protective role of antioxidant vitamin E and catechin on idarubicin-induced cardiotoxicity in rats
Idarubicin is an anthracycline antibiotic extensively used in acute leukemia. In the present study we investigated whether vitamin E and catechin can reduce the toxic effects of idarubicin. Vitamin E (200 IU kg-1 week-1), catechin (200 mg kg-1 week-1), idarubicin (5 mg kg-1 week-1), idarubicin + vitamin E (200 IU kg-1 week-1), and idarubicin + catechin (200
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-11
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8. Heart failure in a 9-year-old child after treatment with anthracycline for Wilms' tumor
Arquivos Brasileiros de Cardiologia. Publicado em: 2000-08
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9. Cardioprotection by ICRF187 against high dose anthracycline toxicity in children with malignant disease.
OBJECTIVE--A pilot study to assess the efficacy of ICRF187 as a protective agent against the cardiotoxic effects of anthracycline drugs used to treat childhood malignancies. DESIGN--A study of cardiac function in children treated receiving ICRF187 ((s)-(+)-1,2 bis (3,5-dioxopiperazenyl) propane) in addition to anthracycline therapy compared with contemporary
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10. Ternary interactions of spermine with DNA: 4'-epiadriamycin and other DNA: anthracycline complexes.
The recently developed anthracycline 4'-epiadriamycin, an anti-cancer drug with improved activity, differs from adriamycin by inversion of the stereochemistry at the 4'-position. We have cocrystallized 4'-epiadriamycin with the DNA hexamer d(CGATCG) and solved the structure to 1.5 A resolution using x-ray crystallography. One drug molecule binds at each d(CG
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11. Left ventricular diastolic function after anthracycline chemotherapy in childhood: relation with systolic function, symptoms, and pathophysiology.
OBJECTIVES--To examine left ventricular (LV) diastolic function in patients previously treated with anthracycline drugs for childhood malignancy. To consider clinical relevance, relations with systolic dysfunction, and the pathophysiology of anthracycline cardiotoxicity. DESIGN--Cross sectional echocardiographic study of LV function. SETTING--Supraregional c
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12. Two modes of longe-range orientation of DNA bases realized upon compaction.
Formation of compact particles from linear DNA-anthracycline complexes is accompanied by appearance of intense bands in the CD spectra in the region of absorption of DNA bases (UV-region) and in the region of absorption of anthracycline chromophores (visible region). The intense (positive or negative) bands in the region of anthracycline absorption demonstra