Antagonists Ions
Mostrando 1-12 de 45 artigos, teses e dissertações.
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1. Efeito do derivado quinazolinico PD153035 sobre a função mitocondrial : implicações na cardioproteção / Effect of the 4-anilinoquinazoline PD153035 on mitochondrial function : implication in cardioprotection
The action of the aminoquinazoline PD153035 on the mitochondrial functions was investigated. The addition of various PD153035 concentrations (5, 10, 20 and 40 μM) to liver mitochondria decreased the mitochondrial respiratory control, induced mitochondrial permeability transition cyclosporin A-sensitive, increased the mitochondrial calcium uptake capacit
Publicado em: 2008
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2. Biodegradabilidade anaerÃbia de Ãgua de produÃÃo de petrÃleo / Anaerobic biodegradability of water from oil production
Durante a extraÃÃo o petrÃleo ocorre a geraÃÃo de um grande volume de Ãgua, chamada de Ãgua de produÃÃo de petrÃleo (AP). Um campo de petrÃleo novo produz pouca Ãgua, porÃm com o passar do tempo e com a exploraÃÃo este volume se eleva em quantidades que inviabilizam a utilizaÃÃo do poÃo. A produÃÃo excessiva desse efluente se tornou uma d
Publicado em: 2008
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3. Efeito de bloqueadores de canais de íons cálcio sobre espermatozóides e oócitos de hamsters fecundados in vivo e in vitro / Effects of calcium ion channel blockers on hamster spermatozoa and oocytes in in vivo and in vitro fertilization
Fertilization process is closely related with calcium ion. There are reports about voltage-dependent calcium ion channel blockers of anti-hypertension therapeutic use causing male infertility, but there are few reports about such effects on the oocyte. The main goal of this experiment was to check the influence of verapamil, nifedipine and diltiazem (L-type
Publicado em: 2004
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4. Mecanismo de transporte iônico em íleo de coelho, induzido por microcistina LR de Microcystis aeruginos: Participação de macrófagos,Il-1beta, TNFalpha e mediadores pró-inflamatórios / Mechanism of ionic transport in ileum rabbit induced by microcystin-LR of Microcystis aeruginosa: Role of macrophages, IL-1b, TNF-a and pro-inflammatory mediators
This work as main objective to evaluate the eletrogenic effect in preparations of íleum of rabbit fixes in chambers of Üssing, in presence of supernatant of macrophages (S.MfS), stimulated with microcistin-LR (MCLR), of Microcystis aeruginosa. S.MfS estimulated with MCLR (3,2.10-7M; 9,6.10-7M e 3,2.10-6M), produces effect secretion, of the form dose-depend
Publicado em: 2003
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5. Involvement of calcium in pain and antinociception
Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and ant
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-04
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6. Modulation of L-type calcium channels by sodium ions.
It is universally believed that the removal of external sodium ions is without effect on calcium current. We now report that in enzymatically isolated guinea pig ventricular cells, the replacement of external sodium ions with certain other cations causes a 3- to 6-fold increase in peak L-type calcium current. The increase in current is reversibly blocked by
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7. [3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.
[3H]Nitrendipine binds with high affinity to brain membranes with a drug specificity indicating association with sites mediating the pharmacologic actions of dihydropyridine slow-calcium-channel antagonist drugs. In brain membranes, [3H]nitrendipine binding is absolutely dependent on the presence of calcium ions. Interactions of cation with [3H]nitrendipine
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8. Recognition of the muscarinic receptor by its endogenous neurotransmitter: binding of [3H]acetylcholine and its modulation by transition metal ions and guanine nucleotides.
Agonist binding to the muscarinic receptor in rat cerebral cortex membranes was studied by using the neurotransmitter itself, [3H]acetylcholine [( 3H]AcCho). By using 10 microM atropine or oxotremorine to define specific binding, it was possible to demonstrate specific binding of [3H]AcCho that was sensitive to muscarinic but not to nicotinic ligands. Equili
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9. The dipeptide carnosine constricts rabbit saphenous vein as a zinc complex apparently via a serotonergic receptor.
1. The endogenous dipeptide carnosine (beta-alanyl-L-histidine), at 0.1-10 mM, provokes sustained contractures in rabbit saphenous vein rings with greater efficacy than noradrenaline (NA). 2. The effects of carnosine are specific; anserine and homocarnosine are ineffective, as are carnosine's constituent amino acids histidine and beta-alanine. 3. Maximum car
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10. Block of current through T-type calcium channels by trivalent metal cations and nickel in neural rat and human cells.
1. The effects of the trivalent cations yttrium (Y3+), lanthanum (La3+), cerium (Ce3+), neodymium (Nd3+), gadolinium (Gd3+), holmium (Ho3+), erbium (Er3+), ytterbium (Yb3+) and the divalent cation nickel (Ni2+) on the T-type voltage gated calcium channel (VGCC) were characterized by the whole-cell patch clamp technique using rat and human thyroid C cell line
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11. Distinct pharmacological properties of excitatory amino acid receptors in the rat striatum: study by Na+ efflux assay.
Specific 22Na+ efflux rates from preloaded rat striatal slices are increased in a dose-dependent manner by L-glutamate and other excitatory amino acids displaying the following order of efficiency: N-methyl-D-aspartate greater than DL-homocysteate greater than quisqualate greater than kainate greater than D-glutamate greater than L-glutamate greater than L-a
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12. Isolation of glutamate transport-coupled charge flux and estimation of glutamate uptake at the climbing fiber–Purkinje cell synapse
Excitatory amino acid transporters (EAATs) located on neurons and glia are responsible for limiting extracellular glutamate concentrations, but specific contributions made by neuronal and glial EAATs have not been determined. At climbing fiber to Purkinje cell (PC) synapses in cerebellum, a fraction of released glutamate is rapidly bound and inactivated by n
National Academy of Sciences.