Anoikis
Mostrando 1-12 de 22 artigos, teses e dissertações.
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1. Células epiteliais exfoliadas: potencial para investigar a maturação gastrointestinal em crianças pré-termo
Células epiteliais exfoliadas são uma fonte de informação valiosa sobre o estado fisiológico da mucosa. Contudo, a interpretação dos dados obtidos de células exfoliadas é complicado pelas condições de isolamento e da saúde do sujeito. A exfoliação é: a) uma perda natural de células implicando um sinal molecular relacionado ao turnover termina
Revista Brasileira de Saúde Materno Infantil. Publicado em: 2010-03
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2. Associação entre Timp1, β1-integrinas e CD63 ao longo da gênese do melanoma. / Association between Timp1, β1-integrin and CD63 during the genesis of melanoma.
O melanoma é o tipo de câncer de pele menos frequente, mas que tem um grande poder de letalidade devido ao seu potencial de formar metástases. Para as células adquirirem a capacidade de formar metástases, estas precisam ter a característica de sobreviver independente de interações com a matriz extracelular e consequentemente apresentar resistência a
Publicado em: 2010
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3. Efeito do silenciamento do supressor de sinalização de citocinas 1 (SOCS-1) em células de melanoma murino B16F10-Nex 2 / The effects of silencing of Supressor of Cytokine Signaling 1 (SOCS-1) in murine melanoma B16F10-Nex2
O melanoma é um tumor de origem neuroectodérmica resultante da proliferação e transformação maligna dos melanócitos, os quais se originam de precursores da crista neural que então migram para a pele e folículos capilares durante o processo de embriogênese, e se apresentam como células especializadas que produzem melanina, encontradas na camada bas
Publicado em: 2010
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4. Reactive oxygen species and angiotensin II signaling in vascular cells: implications in cardiovascular disease
Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including endothelial dysfunction, altered contractility and vascular remodeling. Cellular events underlying these processes involve changes in vascular smooth muscle cell (VSMC) growth, apoptosis/anoikis, cell migration
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-08
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5. Nitric oxide induced adhesion related apoptosis (anoikis) in A431 cells / Indução de apoptose relacionada com perda de adesão (anoikis) em células A431 por óxido nítrico
Células epiteliais, endoteliais e fibroblastos podem ser induzidos a apoptose (anoikis) quando se destacam da matriz extracelular. O processo de anoikis tem a função de proteger o organismo da colonização inapropriada destas células. O processo de apoptose pode ser induzido por vários estímulos, dentre eles, o óxido nítrico (NO). O radical livre NO
Publicado em: 2003
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6. Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase
Activated Ras, but not Raf, causes transformation of RIE-1 rat intestinal epithelial cells, demonstrating the importance of Raf-independent effector signaling in mediating Ras transformation. To further assess the contribution of Raf-dependent and Raf-independent function in oncogenic Ras transformation, we evaluated the mechanism by which oncogenic Ras bloc
American Society for Microbiology.
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7. Matrix-independent Survival of Human Keratinocytes through an EGF Receptor/MAPK-Kinase-dependent Pathway
Normal epithelial cells undergo apoptosis when they are denied contact with the extracellular matrix, in a process termed “anoikis.” Conversely, malignant epithelial cells typically acquire anchorage independence, i.e., the capacity to survive and grow in the absence of matrix interaction. Here we asked the question whether anoikis is affected by si
The American Society for Cell Biology.
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8. Mutation of the Rb1 Pathway Leads to Overexpression of mTor, Constitutive Phosphorylation of Akt on Serine 473, Resistance to Anoikis, and a Block in c-Raf Activation▿ †
Atk can be activated by two independent phosphorylation events. Growth factor-dependent phosphorylation of threonine 308 (Akt-308) by phosphatidylinositol 3-kinase-dependent PDK1 leads to activation of mammalian target of rapamycin (mTor) complex 1 (TORC1) and stimulation of protein synthesis. Phosphorylation on serine 473 (Akt-473) is catalyzed by mTor in a
American Society for Microbiology (ASM).
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9. Golgi Fragmentation Is Associated with Ceramide-induced Cellular Effects
Ceramide has been shown to cause anoikis, a subtype of apoptosis due to inadequate cell adhesion. However, the underlying mechanism is unclear. Herein, we report that D-e-C6-ceramide (D-e-Cer), via generating sphingosine, disrupts the Golgi complex (GC), which is associated with various cellular effects, including anoikis. Treatment of HeLa cells with D-e-Ce
The American Society for Cell Biology.
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10. Raf-MEK-Erk Cascade in Anoikis Is Controlled by Rac1 and Cdc42 via Akt
Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of apoptosis. This pathway of cell death requires the activation of both the p53 tumor suppressor and the extr
American Society for Microbiology.
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11. Silencing of D4-GDI Inhibits Growth and Invasive Behavior in MDA-MB-231 Cells by Activation of Rac-dependent p38 and JNK Signaling
The Rho GDP dissociation inhibitor D4-GDI is overexpressed in some human breast cancer cell lines (Zhang, Y., and Zhang, B. (2006) Cancer Res. 66, 5592–5598). Here, we show that silencing of D4-GDI by RNA interference abrogates tumor growth and lung metastasis of otherwise highly invasive MDA-MB-231 breast cancer cells. Under anchorage-independent cult
American Society for Biochemistry and Molecular Biology.
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12. Helicobacter pylori Supernatants Cause Epithelial Cytoskeletal Disruption That Is Bacterial Strain and Epithelial Cell Line Dependent but Not Toxin VacA Dependent
We show here that Helicobacter pylori broth culture supernatants disrupt the actin cytoskeleton of epithelial cell lines, leading to cell rounding and apoptosis through anoikis. We demonstrate that there are marked quantitative differences between strains and that there are different cell line sensitivities. By constructing VacA null isogenic mutants, we sho
American Society for Microbiology.