Animal Toxicity
Mostrando 13-24 de 235 artigos, teses e dissertações.
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13. Ayahuasca: what mental health professionals need to know
Abstract Background Ayahuasca is a psychoactive ethnobotanical concoction that has been used for decades by indigenous groups of the Northwestern Amazon and by syncretic religious organizations for ritual and therapeutic purposes. In the last two decades, it is being used worldwide in evolving practices. Ayahuasca seem to therapeutic effects, but controlle
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2017-08
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14. Ultrasound as a safe and reliable guidance for subarachnoid puncture in rabbits
Abstract Purpose: To evaluate a model for studying the toxicity in nervous tissue and meninges using ultrasound to guide needle insertion into the subarachnoid space of rabbits, with the objective of avoiding injuries triggered by the puncture and by intraneural injection of solutions. Methods: Forty-five adult female rabbits were divided into 3 groups (G
Acta Cir. Bras.. Publicado em: 2017-01
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15. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies
The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through severa
Braz J Med Biol Res. Publicado em: 12/12/2016
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16. The Effect of Jatropha Curcas Seed Meal on Growth Performance and Internal Organs Development and Lesions in Broiler Chickens
ABSTRACT The meal of Jatropha curcas (JCM) seed is a by-product of the biofuel industry and may potentially to be used as animal feed. However, its toxicity has prevented its utilization in animal nutrition mainly due to its high concentration of phorbol esters. This study was conducted to evaluate the effects of the dietary inclusion of JCM on the growth pe
Rev. Bras. Cienc. Avic.. Publicado em: 2015-12
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17. Cytolytic and systemic toxic effects induced by the aqueous extract of the fire coral Millepora alcicornis collected in the Mexican Caribbean and detection of two types of cytolisins
AbstractBackground Millepora alcicornis is a branching hydrocoral common throughout the Caribbean Sea. Like other members of this genus, this species is capable of inducing skin eruptions and blisters with severe pain after contact. In the present study, we investigated the toxicity of theM. alcicornis aqueous extract on several animal models. Considering th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/10/2015
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18. Preliminary screening of the larvicidal effect of Brevibacillus laterosporus strains against the blowfly Chrysomya megacephala(Fabricius, 1794) (Diptera: Calliphoridae)
AbstractINTRODUCTION: This study evaluated whether different strains of Brevibacillus laterosporus could be used to control larvae of the blowfly Chrysomya megacephala , a pest that affects both human and animal health.METHODS:Mortality rates were recorded after 1-mL suspensions of sporulated cells of 14 different strains of B. laterosporus were added to 2.5
Rev. Soc. Bras. Med. Trop.. Publicado em: 2015-08
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19. Anti-inflammatory action of Justicia acuminatissima leaves
AbstractIn Amazonas State (Brazil), Justicia acuminatissima (Miq.) Bremek., Acanthaceae, leaf teas are used in folk medicine to treat several inflammatory illnesses. In order to validate this medicinal application, we analyzed the acute toxicity and antioxidant, antiedematogenic and antinociceptive potentials of an aqueous extract of this species, using cult
Rev. bras. farmacogn.. Publicado em: 2015-06
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20. Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Siphonops annulatus
Background Among the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. The pr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/01/2015
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21. A CssA, CssB and LTB chimeric protein induces protection against Enterotoxigenic Escherichia coli
OBJECTIVES: Enterotoxigenic Escherichia coli (ETEC), a major cause of diarrhea in children under 5, is an important agent for traveler's diarrhea. Heat-labile enterotoxin (LT) and colonization factors (CFs) are two main virulence mechanisms in ETEC. CS6 is one of the most prevalent CFs consisting of two structural subunits viz., CssA, CssB, necessary for a
Braz J Infect Dis. Publicado em: 2014-06
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22. REFRIAMENTO DO SÊMEN DE Colossoma macropomum EM ÁGUA DE COCO EM PÓ (ACP-104) ASSOCIADA À CRIOPROTETORES - ESTUDO DE TOXICIDADE / REFRIAMENTO OF SEMEN Colossoma macropomum WATER COCONUT POWDER (ACP-104) ASSOCIATED cryoprotectants - TOXICITY STUDY
Os peixes da espécie Colossoma macropomum (tambaqui) tem um alto valor econômico e ecológico. Uma tecnologia que vêm se destacando nos últimos anos é a conservação de sêmen realizada por resfriamento. Dessa forma, o estudo tem como objetivo avaliar a qualidade do sêmen de tambaqui em solução de água de coco em pó específico para peixes (ACP-10
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/07/2012
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23. Efeitos do inseticida endossulfam sobre a morfologia e a morfometria testicular em morcegos frugívoros Artibeus lituratus (OLFERS, 1818) / Effects of the endosulfan on the testicular morphology and morphometry in fruit bats Artibeus lituratus (OLFERS, 1818)
Large amounts of agricultural chemicals are discharged into the environment in Brazil. These pesticides are often used to destroy or impair the activity of organisms that attack crops. There are some reports in the literature concerning the decline of many wildlife populations as a result of contamination of their habitats by pesticides. One of the putative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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24. Complexos metálicos de hidrazonas, tiossemicarbazonas e lapachol: atividade farmacológica e avaliação de relações estrutura-atividade
The present work comprises the synthesis and characterization of metal compounds with bioactive ligands and the study of their pharmacological profile. Anti-inflammatory, antimicrobial, antiparasitic and antitumor drug candidates were designed. Complex [Zn(LASSBio-466)H2O]2 was synthesized with salicylaldehyde-2-chlorobenzoyl hydrazone (H2LASSBio-466), while
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012