Animal Model Of Anxiety
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. ROLE OF DORSAL AND VENTRAL HIPPOCAMPUS ON CONDITIONED AND UNCONDITIONED FEAR ELICITED BY DORSAL PERIAQUEDUCTAL GREY MATTER ELECTRICAL STIMULATION IN RATS / PARTICIPAÇÃO DO HIPOCAMPO DORSAL E VENTRAL NAS REAÇÕES DE DEFESA PRODUZIDAS PELO CONDICIONAMENTO CONTEXTUAL DE MEDO E PELA ESTIMULAÇÃO ELÉTRICA DA MATÉRIA CINZENTA PERIAQUEDUTAL DORSAL
This study investigates the role of the hippocampus in both unconditioned and conditioned defense behavior by examining the effects of pre-training electrolytic lesions to the dorsal and ventral hippocampus in male rats exposed to two types of threat stimuli: electrical stimulation of the DPAG and footshock. Our results indicate that ventral and dorsal lesio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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2. Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze
The escape response to electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) has been associated with panic attacks. In order to explore the validity of the DPAG stimulation model for the study of panic disorder, we determined if the aversive consequences of the electrical or chemical stimulation of this midbrain area can be dete
Braz J Med Biol Res. Publicado em: 2012-11
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3. Subchronic effects of fluoxetine on conditioned suppression produced by a hot air blast
Conditioned suppression is an animal model of anxiety disorders that has been broadly used to investigate the behavioral effects of different drugs. However, various methodological variables (e.g., the type of aversive stimulus) that supposedly interfere with the acquisition of conditioned suppression may also contribute to conflicting results among the stud
Psychol. Neurosci.. Publicado em: 2012-06
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4. New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray
Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal th
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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5. Influência dos hormônios sexuais na analgesia induzida pelo estresse / Influence of sex hormones in stress-induced analgesia
Temporomandibular disorders comprehend a variable group of conditions which result in joint and/or muscle pain and contribute to the development of acute pains, being more prevalent in women than men, especially during the reproductive period. They involve the muscles of mastication and temporomandibular joint (ATM), being usually associated with inflammator
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2011
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6. Efeito ansiolítico do ondansetron, antagonista dos receptores 5-HT3, injetado na amídala de camundongos submetidos à exposição e reexposição no labirinto em cruz elevado
Against of stimuli that are dangerous, animals manifest defense reactions that cause fear and anxiety. These stimuli activate the serotonergic system, which sends projections to structures involved in defense mechanisms such as the septum, hypothalamus, hippocampus, amygdala and periaqueductal gray modulates the behavioral changes that can be characterized a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2011
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7. Panic-like behaviors in Carioca High-and Low-conditioned Freezing rats
Panic disorder involves both recurrent unexpected panic attacks and persistent concern about having additional attacks. Electrical stimulation of the dorsal periaqueductal gray (dPAG) is an animal model of both panic attack and panic disorder, whereas contextual fear conditioning represents a model of anticipatory anxiety. Previous research indicated that an
Psychology & Neuroscience. Publicado em: 2011
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8. Estudo translacional sobre a qualidade do cuidado materno em resposta ao estresse neonatal, sua associação com ansiedade na vida adulta e investigação de potenciais mecanismos envolvidos
Introduction: In humans, there is the suggestion that an adverse early life environment is related to the development of anxiety disorders in adulthood. This association could potentially be mediated by stress responses, brain-derived neurotrophic factor (BDNF) and by neuronal nitric oxide synthase (nNOS). This study aimed at proposing an animal model for th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011
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9. Effects of curcumin on pentylenetetrazole-induced anxiety-like behaviors and associated changes in cognition and monoamine levels
The purpose of the present study was to estimate the protective effects of curcumin against anxiety and memory impairment, which are often comorbid in patients with anxiety disorders who are on standard anxiolytic therapy. The effects of curcumin on brain monoamine levels were also determined. We used the elevated plus maze (EPM), a standard animal model of
Psychology & Neuroscience. Publicado em: 2010-12
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10. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate
Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) a
Psychology & Neuroscience. Publicado em: 2010-06
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11. Dose-related effects of propericiazine in rats
We evaluated the effects of the neuroleptic agent propericiazine on animal models of anxiety and memory. Adult male Wistar rats (250 to 350 g) received intraperitoneal injections of propericiazine (0.05, 0.075 and 0.1 mg/kg), diazepam (1 mg/kg), saline, or diazepam vehicle (20% propylene glycol and 80% saline) 30 min prior to the experimental procedure. Anim
Publicado em: 2010
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12. Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao labirinto em cruz elevado promove efeito ansiolítico que é revertido pelo prétratamento local com WAY100635
Research on anxiety often involves the use of animal models for investigation of therapeutic compounds. Thus, the elevated plus maze (EPM) is one of the most commonly model used in research involving anxiety and it has been validated for rats and mice. Serotonin (5-HT) is a neurotransmitter involved not only in anxiety but also in other disorders. Some repor
Publicado em: 2010