Animal Growth Regulator
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding, and which has a greater affinity. Fusion of specific antigens to extracellular domain of CTLA4 represents a promising approach to increase the immunogenicity of DNA vaccines. In this study, we evaluated this inter
Braz J Med Biol Res. Publicado em: 24/10/2016
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2. Ação do regulador de crescimento de artrópodes, piriproxifen, sobre Rhipicephalus sanguineus (Latreille, 1806), em infestações artificiais, em coelhos. Seropédica / Action of arthropod growth regulator, pyriproxyfen, on Rhipicephalus sanguineus (Latreille, 1806) in artificial infestations in rabbits. Seropédica
A realização deste estudo teve como objetivo avaliar as alterações morfológicas e biológicas apresentadas em diferentes fases evolutivas de Rhipicephalus sanguineus submetidos ao regulador de crescimento de artrópodes (AGRs), piriproxifen, em coelhos tratados. O trabalho foi realizado nas dependências do Laboratório de Quimioterapia Experimental em
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/12/2010
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3. Effect of growth hormone on fatty acid synthase gene expression in growing animals. / Efeito do hormônio do crescimento na expressão gênica da sintetase de ácidos graxos em animais em crescimento.
A somatotropina (ST) pode reduzir a deposição de gordura em suínos, em crescimento em até 90%. Este efeito parece ser função de diversas alterações no metabolismo do tecido adiposo, incluindo a redução na atividade da sintetase de ácidos graxos (FAS), considerada uma enzima limitante na via da síntese de lipídeos de novo. A atividade da FAS pare
Publicado em: 2000
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4. GacA Regulates Symbiotic Colonization Traits of Vibrio fischeri and Facilitates a Beneficial Association with an Animal Host
The GacS/GacA two-component system regulates the expression of bacterial traits during host association. Although the importance of GacS/GacA as a regulator of virulence is well established, its role in benign associations is not clear, as mutations in either the gacS or gacA gene have little impact on the success of colonization in nonpathogenic association
American Society for Microbiology.
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5. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
4E-BP is an important regulator of overall translation levels in cells. By binding eIF4E, 4E-BP impairs recruitment of the 40S ribosomal subunit to the cap structure present at the 5′-end of all eukaryotic cellular mRNAs. 4E-BP activity is controlled by TOR (Target of Rapamycin). 4E-BP has been studied extensively in cell culture; however, the biological r
Cold Spring Harbor Laboratory Press.
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6. Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium
In the seminiferous epithelium, Eps8 is localized to actin-based cell junctions at the blood-testis barrier (BTB) and the apical ectoplasmic specialization (ES) in stage V–VI tubules but is considerably diminished in stage VIII tubules. Eps8 down-regulation coincides with the time of BTB restructuring and apical ES disassembly, implicating the role of Eps8
The Federation of American Societies for Experimental Biology.
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7. Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
Prostate cancer (PCa) is an androgen dependent disease that can be treated by androgen ablation therapy, and clinical trials are under way to prevent PCa through the reduction of androgen receptor (AR) activity. However, there are no animal models of AR-mediated prostatic neoplasia, and it remains unclear whether the AR is a positive or negative regulator of
The National Academy of Sciences.
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8. Regulation of cellular growth by the Drosophila target of rapamycin dTOR
The TOR protein kinases (TOR1 and TOR2 in yeast; mTOR/FRAP/RAFT1 in mammals) promote cellular proliferation in response to nutrients and growth factors, but their role in development is poorly understood. Here, we show that the Drosophila TOR homolog dTOR is required cell autonomously for normal growth and proliferation during larval development, and for inc
Cold Spring Harbor Laboratory Press.
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9. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development
The transcription factor dMyc is the sole Drosophila ortholog of the vertebrate c-myc protooncogenes and a central regulator of growth and cell-cycle progression during normal development. We have investigated the molecular basis of dMyc function by analyzing its interaction with the putative transcriptional cofactors Tip48/Reptin (Rept) and Tip49/Pontin (Po
National Academy of Sciences.
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10. Mechanical feedback as a possible regulator of tissue growth
Regulation of cell growth and proliferation has a fundamental role in animal and plant development and in the progression of cancer. In the context of development, it is important to understand the mechanisms that coordinate growth and patterning of tissues. Imaginal discs, which are larval precursors of fly limbs and organs, have provided much of what we cu
National Academy of Sciences.
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11. Expression of galectin-3 modulates T-cell growth and apoptosis.
Galectin-3 is a member (if a large family of beta-galactoside-binding animal lectins. It has been shown that the expression of galectin-3 is upregulated in proliferating cells, suggesting a possible role for this lectin in regulation of cell growth. Previously, we have shown that T cells infected with human T-cell leukemia virus type I express high levels of
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12. Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice
The relationship between abnormal cell proliferation and aberrant control of hormonal secretion is a fundamental and poorly understood issue in endocrine cell neoplasia. Transgenic mice with parathyroid-targeted overexpression of the cyclin D1 oncogene, modeling a gene rearrangement found in human tumors, were created to determine whether a primary defect in
American Society for Clinical Investigation.