Angiogenic Proteins
Mostrando 1-12 de 45 artigos, teses e dissertações.
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1. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model
Abstract Background: The great diversity of molecules found in spider venoms include amino acids, polyamines, proteins and peptides, among others. Some of these compounds can interact with different neuronal receptors and ion channels including those present in the ocular system. To study potential toxicity and safety of intravitreal injection in rabbits of
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 17/12/2018
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2. Osseointegração de implantes em defeitos circunferenciais utilizando proteínas angiogênicas purificadas do látex, osso autógeno e regeneração óssea guiada. Estudo comparativo em mandíbulas de cães / Implant osseointegration in circumferential bone defects using latexderived proteins, autogenous bone graft and guided bone regeneration. A comparative study in the dog mandible
The development of biomaterials that can assist osseointegration and implant stability in dissatisfactory anatomical regions has been the goal of several researches in the past years. Despite the array of regenerative therapies to be used, some clinical disadvantages still persist, such as considerable patient morbidity, extended patient recovery periods, su
Publicado em: 2009
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3. Aspectos celulares, teciduais e moleculares da osteogênese ectópica e ortotópica induzida pela matriz alogênica óssea e dentinária / Cellular, tissue and molecular aspects of the ectopic and orthotopic osteogenese induced by bone and dentine allogenic matrix
The aim of the present work was to correlate the cellular and tissue events with the expression of VEGF, BMP-7, RANKL and OPG during ectopic and orthotopic osteogenesis, induced by bone and dentin allogeneic matrix. Allogenic matrices obtained from femur and incisor of rats and demineralized in 0.6 N HCl were implanted into a intramuscular pocket and a 8mm-d
Publicado em: 2009
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4. Expressão de fatores angiogênicos em corpo lúteo cíclico e superovulado de búfalas / Expression of angiogenic factors in cyclic and superovulated bufallo corpus luteum
Biotechniques can be an effective way of improving reproduction efficiency and enhancing the production of genetically superior animals. The superovulatory treatment is a common technique aiming to spread desired genetical material, although its use in buffalos still presents limitations, mainly the low embryo recovery rate. The corpus luteum (CL) is a tempo
Publicado em: 2008
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5. Individual risk prediction of node and distant metastasis based on lymphangiogenic intensity in typical pulmonary carcinoid tumor / Predição do risco individual de metástase linfática e hematogênica em função da intensidade da linfangiogênese no tumor carcinóide típico broncopulmonar
Typical pulmonary carcinoids are neuroendocrine cells proliferations and they were former considered lung adenomas with no hematogenic or lymphatic metastatic potential. However, it is known that up to 20% of patients develop metastatic disease. It is mandatory that new studies be developed due to the variation in clinical presentation of these patients. It
Publicado em: 2008
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6. ROLE OF Bcl-2 AND Bcl-XL IN ANGIOGENESIS
(...)Angiogenesis is defined as the development of new capillaries from pre-existing blood vessels. The hypothesis that tumor growth is angiogenesis dependent was proposed by Judah Folkman in 1971, and it has been confirmed by many investigators thereafter. We have shown that vascular endothelial growth factor (VEGF) induces Bcl-2 expression in endothelial c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2006
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7. Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1
The ECM protein Del-1 is one of several novel ECM proteins that accumulate around angiogenic blood vessels in embryonic and tumor tissue and promote angiogenesis in the absence of exogenous growth factors. Del-1 expressed in mouse or rabbit ischemic hind-limb muscle by gene transfer rapidly promotes new blood vessel formation and restores muscle function. Th
American Society for Clinical Investigation.
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8. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature
A group of angiogenesis inhibitors are derived from fragments of extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin are members of this group of substances. The plasma adhesion proteins fibronectin and vitronectin serve as cofactors for these three antiangiogenic proteins. Anginex is a synthetic 33-amino acid peptide that was or
National Academy of Sciences.
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9. Microparticles harbouring sonic hedgehog: Role in angiogenesis regulation
Sonic Hedgehog (Shh) is a morphogen involved in embryonic development of nervous system. Also, it has been shown that recombinant Shh can modulate angiogenesis under ischemic conditions. However, angiogenic effects of endogenous Shh have not been completely elucidated. Using small membrane-derived vesicles expressing Shh (MPsShh+), we have shown that, althou
Landes Bioscience.
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10. Cytokine therapeutics: lessons from interferon alpha.
Cytokines are soluble proteins that allow for communication between cells and the external environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control
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11. Characterization of mouse angiogenin-related protein: implications for functional studies on angiogenin.
Angiogenin-related protein (Angrp), the putative product of a recently discovered mouse gene, shares 78% sequence identity with mouse angiogenin (Ang). In the present study, the relationship of Angrp to Ang has been investigated by producing both proteins in bacteria and comparing their functional properties. We find that mouse Ang is potently angiogenic, bu
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12. The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
The etiology and progression of a variety of human malignancies are linked to the deregulation of receptor tyrosine kinases (RTKs). To define the role of RTK-dependent signals in various oncogenic processes, we have previously engineered RTK oncoproteins that recruit either the Shc or Grb2 adaptor proteins. Although these RTK oncoproteins transform cells wit
National Academy of Sciences.