Angiogenesis Inhibitors
Mostrando 13-24 de 91 artigos, teses e dissertações.
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13. Esôfago de Barrett: aspectos fisiopatológicos e moleculares da seqüência metaplasia-displasia-adenocarcinoma - artigo de revisão
The Barrett's esophagus (BE) is defined as endoscopically visible columnar mucosa at the distal esophagus, of any extension, proved to harbor intestinal metaplasia on biopsy, highlighted by the presence of goblet cells. BE denotes long-standing gastroesophageal reflux disease (GERD) and is an important risk factor for the development of esophageal adenocarci
Revista do Colégio Brasileiro de Cirurgiões. Publicado em: 2008-04
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14. Effect of vascular endothelial growth factor receptors inhibition on tumor angiogenesis in head and neck squamous cell carcinoma / Efeito da inibição dos receptores de fator de crescimento endotelial vascular na angiogênese tumoral em carcinomas espinocelulares de cabeça e pescoço
O fator de crescimento endotelial vascular (VEGF) tem sido considerado o principal indutor da angiogênese tumoral por sua ligação a receptores específicos tirosina-quinase presentes nas células endoteliais (VEGFR). Uma importante via reguladora da angiogênese é caracterizada pela ligação do VEGF ao seu receptor VEGFR-2 ativando a via de sinalizaçã
Publicado em: 2007
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15. Definição de alvos moleculares em diferenciação, morte e resistencia de celulas tumorais / Defenition of molecular targets indifferentiation, death and resisteance in cancer cells
Cancer therapy efficiency, under several aspects, even with the progress of pharmacotechnology, remains as a challenge for the medicine. According to this factor, new agents that act on specific target, present low side-effects and prevent cancer cells escaping from death induction, are extremely desirable. In this work, 3 aspects of antitumoral prop
Publicado em: 2007
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16. Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors
Disruption of the systemic angiogenesis balance to favor enhanced angiogenesis is speculated to represent a key step in the growth of tumors. Although a major emphasis has been placed on the increase of angiogenesis stimulators, such as VEGF, on the disruption of the angiogenic balance, the potential role of the physiological levels of endogenous inhibitors
National Academy of Sciences.
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17. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases
This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process for growth and tissue repair after injury. Nevertheless, it may contribute to a variety of chronic inflammatory diseases, including rheumatoid arthritis, osteoarthrit
BioMed Central.
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18. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.
We evaluated the effects of nitric oxide (NO) generators and endogenous production of NO elicited by substance P (SP) in the angiogenesis process. Angiogenesis was monitored in the rabbit cornea in vivo and in vitro by measuring the growth and migration of endothelial cells isolated from coronary postcapillary venules. The angiogenesis promoted in the rabbit
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19. Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
Angiogenesis is activated during multistage tumorigenesis prior to the emergence of solid tumors. Using a transgenic mouse model, we have tested the proposition that treatment with angiogenesis inhibitors can inhibit the progression of tumorigenesis after the switch to the angiogenic phenotype. In this model, islet cell carcinomas develop from multifocal, hy
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20. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
Id proteins bind basic helix–loop–helix transcription factors and function as dominant negative inhibitors of gene expression. Id1 and Id3 are required for the recruitment of bone marrow-derived endothelial cell precursors and tumors transplanted into Id-deficient mice demonstrate impaired angiogenesis. Mouse mammary tumor virus–neu mice were bred with
National Academy of Sciences.
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21. Vasohibin: the feedback on a new inhibitor of angiogenesis
Angiogenesis is regulated in large part by the balance of various proangiogenic stimulators, such as VEGF, and a diverse group of endogenous inhibitors of angiogenesis, most of which are extrinsic to endothelial cells. With respect to the latter, until recently, none have appeared to be induced as a consequence of a specific, self-regulating, feedback inhibi
American Society for Clinical Investigation.
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22. Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation
Hepatocyte growth factor/scatter factor (HGF/SF), acting through the Met receptor, plays an important role in most human solid tumors, and inappropriate expression of this ligand–receptor pair is often associated with poor prognosis. The molecular basis for the malignant potential of the HGF/SF–Met signal in cancer cells has mostly been attributed to its
National Academy of Sciences.
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23. Troponin I is present in human cartilage and inhibits angiogenesis
Cartilage is an avascular and relatively tumor-resistant tissue. Work from a number of laboratories, including our own, has demonstrated that cartilage is an enriched source of endogenous inhibitors of angiogenesis. In the course of a study designed to identify novel cartilage-derived inhibitors of new capillary growth, we have purified an inhibitory protein
The National Academy of Sciences.
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24. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature
A group of angiogenesis inhibitors are derived from fragments of extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin are members of this group of substances. The plasma adhesion proteins fibronectin and vitronectin serve as cofactors for these three antiangiogenic proteins. Anginex is a synthetic 33-amino acid peptide that was or
National Academy of Sciences.