Androgens Receptors
Mostrando 1-12 de 41 artigos, teses e dissertações.
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1. Classic and current concepts in adrenal steroidogenesis: a reappraisal
ABSTRACT Adrenal steroid biosynthesis and its related pathology are constant evolving disciplines. In this paper, we review classic and current concepts of adrenal steroidogenesis, plus control mechanisms of steroid pathways, distribution of unique enzymes and cofactors, and major steroid families. We highlight the presence of a “mineralocorticoid (MC) pat
Archives of Endocrinology and Metabolism. Publicado em: 2022
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2. Desenvolvimento da próstata masculina e feminina do gerbilo da Mongólia submetido à exposição no período embriofetal e pós-natal de etinilestradiol / Development of male and female prostate of the Mongolian gerbil submitted to the exposure embryofetal period and postnatal ethinylestradiol
In males, prostatic morphogenesis is an event controlled by androgens, which act directly via paracrine factors secreted by the mesenchyme. In females, the embryological development of the prostate appears to occur in environment low levels of steroid hormones, but the presence of these hormones in the adult life induces differentiation and secretory activit
Publicado em: 2010
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3. Analise molecular do gene do receptor de androgenos em pacientes 46, XY com ambiguidade genital e produção normal de testosterona / Molecular analysis of the androgen receptor gene in patient 46, XY presenting genital ambiguity and normal testosterone production
Considera-se que insensibilidade androgênica seja a causa mais freqüente dos distúrbios da diferenciação do sexo em pacientes com cariótipo 46,XY. Trata-se de uma anomalia recessiva ligada ao cromossomo X, que pode se manifestar de forma branda, parcial ou completa, com um amplo espectro de variação fenotípica. O gene do receptor de andrógenos (AR)
Publicado em: 2010
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4. Estrogens and male reproduction: a new concept
The mammalian testis serves two main functions: production of spermatozoa and synthesis of steroids; among them estrogens are the end products obtained from the irreversible transformation of androgens by a microsomal enzymatic complex named aromatase. The aromatase is encoded by a single gene (cyp19) in humans which contains 18 exons, 9 of them being transl
Brazilian Journal of Medical and Biological Research. Publicado em: 2007-06
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5. Androgen receptors expression in the Mongolian gerbil ventral prostate / Expressão de receptores androgenicos no lobulo ventral da prostata do gerbilo da Mongolia
The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses to hormones under several conditions and the effect of their blockage is due to the fact that the human prostate is the site of a grea
Publicado em: 2007
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6. Estudo da expressão dos receptores do peptídeo insulinotrópico dependente de glicose (GIPR) e do hormônio luteinizante (LHCGR) em tumores e hiperplasias do córtex adrenal / Expression Study of Glucose-dependent insulinotropic peptide receptor (GIPR) and luteinizing hormone receptor (LHCGR) in adrenocortical tumors and hyperplasia
Introduction: The glucose- dependent insulinotropic peptide receptor (GIPR) and luteinizing hormone receptor (LHCGR) are G-protein coupled receptors with a wide tissue expression pattern. The aberrant expression of these receptors has been described in cases of ACTH-independent macronodular adrenal hyperplasia (AIMAH) and in some adenomas, resulting in the i
Publicado em: 2007
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7. Acidos graxos com diferentes caracteristicas afetam o crescimento prostatico e a expressão dos receptores de androgeno (AR) e dos ativadores da proliferação dos peroxissomos y (PPARy) / Dietary fatty acids regulate AR and PPARy levels and prostate growth
A próstata é uma glândula acessória do trato reprodutor masculino. Muitos são os fatores envolvidos no carcinogênese prostática. Os nutricionais são usualmente associados com a etiopatogenia do câncer de próstata, sendo que os ácidos graxos estão entre os mais importantes. O objetivo deste trabalho foi avaliar o efeito dos ácidos graxos presente
Publicado em: 2007
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8. A prostata ventral do gerbilo frente as diferentes formas de castração e subsequente reposição hormonal pela testosterona
The prostate is an exocrine gland of the male genital system, which secretes part of seminal liquidolts differentiation initiates in the beginning of the embryonic development and finishes during the puberty. Testosterone (T) plays an essential role in prostate maintenance, after transformation, by 5a-reductase enzyme, to dehidrotestostorone (DHT) an more po
Publicado em: 2005
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9. Effects of Androgen Treatment on Expression of Macrophage Fcγ Receptors
Macrophage Fcγ receptors (FcγRs) play an important role in the host defense against infection and in the pathophysiology of immune cytopenias. Modulation of macrophage FcγR expression is a potential therapeutic approach to immune disorders. Glucocorticoids and progesterones decrease macrophage FcγR expression. We assessed the effect of treatment with and
American Society for Microbiology.
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10. Evidence that androgens are the primary steroids produced by Xenopus laevis ovaries and may signal through the classical androgen receptor to promote oocyte maturation
Steroid-induced maturation of Xenopus oocytes has long served as a model for studying meiosis. Progesterone has been considered the relevant steroid controlling maturation, perhaps through interactions with classical progesterone receptors. In this study, we provide evidence that androgens, rather than progesterone, are the physiologic mediators of Xenopus o
The National Academy of Sciences.
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11. Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO),
The National Academy of Sciences.
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12. Androgen regulation by the long terminal repeat of mouse mammary tumor virus.
Mouse mammary tumor virus (MMTV) has long been implicated in mouse mammary carcinogenesis, and it is now well established that the long terminal repeat (LTR) contains regulatory sequences responsible for glucocorticoid-mediated induction of viral RNA. However, we have demonstrated previously that androgens as well as glucocorticoids can regulate MMTV RNA in