Amylin
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. Subclinical Diabetes
ABSTRACT Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide, and those non-diagnosed or misdiagnosed comprise a significant group compared to those diagnosed. Accumulated scientific evidence indicate that the current diagnostic markers (fasting glycemia, 2h glycemia after an oral glucose load and HbA1c) are indeed late diagnostic criteria
An. Acad. Bras. Ciênc.. Publicado em: 04/05/2017
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2. Correlations between endogen amylin hormone and some hormonal, biochemical and bone parameters in pullets
The objective of this study was to assess the correlations of amylin (a pancreatic polypeptide hormone) with some hormonal, biochemical and bone parameters in pullets. Forty 18-week-old pullets were used. Plasma amylin, CT (calcitonin), 1,25 (OH)2 vitamin D (1,25 dihydroxycholecalciferol ), serum osteocalcin, glucose, ALP (alkaline phosphatase), cholesterol,
Rev. Bras. Cienc. Avic.. Publicado em: 2014-12
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3. Amylin induces hypoglycemia in mice
Amilina é uma proteína de 37 aminoácidos que exerce controle sobre diversos eventos metabólicos, tais como glicemia e lacticemia. Tem sido mostrado que amilina induz aumento da glicemia plasmática arterial. Nós decidimos investigar se amilina exerce função adicional na regulação do metabolismo de glicose. Nós avaliamos a homeostase de glicose empr
An. Acad. Bras. Ciênc.. Publicado em: 01/03/2013
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4. O efeito pró-apoptótico de oligômeros da amilina humana não é potencializado pela lipotoxicidade em ilhotas pancreáticas de rato em cultura / The pro-apoptotic effect of human amylin oligomers is not potentiated by lipotoxicity in rat pancreatic islets in culture
The amyloid deposit is a common histopathological feature in patients with type 2 diabetes mellitus (T2DM) and it seems to be related to the pancreatic beta cell dysfunction characteristic of this disease. A study previously developed in our laboratory found that human amylin oligomers decrease mRNA expression of the glucose-dependent insulinotropic polypept
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/07/2012
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5. Regulação endócrina de curto prazo de hormônios relacionados à fome em mulheres obesas que apresentam episódios de compulsão alimentar / Short-term endocrine regulation of hunger related hormones in obese women with binge eating episodes
Binge eating is associated to several diseases, including obesity. In order to study the hormonal control of hunger and satiety that is commonly involved in binge-eating process; we evaluated the serum concentration of these hormones in adult women. The experimental study was composed of 3 groups, n= 23: Lean (GE, n = 8), Obese without binge (GO, n = 7) and
Publicado em: 2010
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6. Perfil de expressão de genes modulados pela amilina em ilhotas pancreáticas de rato / Gene expression profile of genes modulated by amylin in rat pancreatic islets
O Diabetes Mellitus tipo 2 (DM 2) é uma doença crônica na qual os pacientes apresentam capacidade secretória de insulina inadequada para suplantar a resistência insulínica concomitante e, como resultado, advém a hiperglicemia. Os mecanismos que explicam a diminuição da secreção insulínica não são completamente conhecidos e acredita-se que o dep
Publicado em: 2009
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7. Rat amylin: cloning and tissue-specific expression in pancreatic islets.
Amyloid deposits in the islets of Langerhans of the pancreas are a common finding in non-insulin-dependent diabetes mellitus. The main protein constituent of these deposits is a 37-amino acid peptide known as amylin that resembles calcitonin gene-related peptide, a neuropeptide. We have isolated cDNA clones corresponding to the rat amylin precursor from an i
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8. Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment.
Amylin, a peptide copackaged with insulin in beta-cell granules, was measured in the effluent of the perfused rat pancreases by means of a newly developed specific radioimmunoassay. Its secretion parallels that of insulin in response to 20 mM glucose, 10 mM arginine, or the combination thereof. The relative molar amount of secreted amylin was estimated to be
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9. Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.
The 37-amino acid peptide called amylin is a major component of the islet amyloid deposited in the pancreases of persons with type 2 diabetes mellitus. We report the isolation of a partial cDNA clone and a phage lambda genomic clone of the coding region of the amylin gene. The DNA sequence encodes a protein sequence identical to that of amylin isolated from
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10. Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling.
The release of insulin from the pancreatic beta cell is dependent upon a complex interplay between stimulators and inhibitors. Recently, amylin, a peptide secreted by pancreatic beta cells, has been implicated in the development of type II (noninsulin dependent) diabetes through its modulation of the peripheral effects of insulin. However, the effect of amyl
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11. Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle.
Diabetes-associated peptide has recently been isolated and characterized from the amyloid of the islets of Langerhans in type 2 (non-insulin-dependent) diabetics, and immunoreactivity with antibodies to the peptide has been demonstrated in islet B cells of both normal and type 2 diabetic subjects. In view of the evidence presented in this paper that this 37-
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12. Dynamic α-Helix Structure of Micelle-bound Human Amylin*
Amylin is an endocrine hormone that regulates metabolism. In patients afflicted with type 2 diabetes, amylin is found in fibrillar deposits in the pancreas. Membranes are thought to facilitate the aggregation of amylin, and membrane-bound oligomers may be responsible for the islet β-cell toxicity that develops during type 2 diabetes. To better understan
American Society for Biochemistry and Molecular Biology.