Amphiphilic Derivatives
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Synthesis and Antioxidant and Antimicrobial Properties of β-Hydroxy Sulfides, Sulfoxides, and Sulfones Derived from Cardanol and Glycerol Derivatives
Natural and synthetic sulfur-bearing organic compounds have many applications in medicinal chemistry. This article reports the preparation of amphiphilic β-hydroxy sulfides, sulfoxides, and sulfones derived from cardanol and glycerol. Thiolysis of cardanol epoxide 3 with various thiols (4a-4j) in ethanol or water yielded the corresponding β-hydroxy sulfide
J. Braz. Chem. Soc.. Publicado em: 2020-12
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2. Chlorophyllin Derivatives as Photosensitizers: Synthesis and Photodynamic Properties
Two new photosensitizers (PSs) derived from copper-chlorophyllin were designed to have excitation wavelengths appropriate for the use in photodynamic therapy (PDT) and to have amphiphilic character with positive charge, which favors binding to cell membranes and walls and the intracellular localization in mitochondria. Herein we describe the synthesis and ch
J. Braz. Chem. Soc.. Publicado em: 2015-12
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3. Avaliação da atividade antimicrobiana, mutagênica e toxicidade aguda de derivados anfifílicos da o-carboximetilquitosana / Evaluation of antimicrobial, mutagenic activity and acute toxicity of amphifilic derivatives of O-carboxymethylchitosan
The chitosan (Ch), a semi-synthetic derivative biopolymer obtained by deacetylation of chitin, has attracted the attention of researchers due to its multiple bioactivities such as hemostasis, antimicrobial, biodegradable, and low oral toxicity. Chitosan inhibits the growth of a wide variety of bacteria and fungi showing a broad spectrum of antimicrobial acti
Publicado em: 2010
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4. Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
Diaminas N-monoalquiladas foram sintetizadas e tratadas com D-ribonolactona ou D-gliconolactona. As aldonamidas resultantes foram avaliadas para atividade antimicrobiana contra S. aureus, E. coli, M. tuberculosis and C. albicans. Duas hidrazidas foram também preparadas a partir da ribonoidrazida e suas atividades biológicas comparadas com aquelas de análo
Journal of the Brazilian Chemical Society. Publicado em: 2008
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5. Obtaining amphiphilic derivatives from o-carboxymethylchitosan and their application for increasing solubility of a low solubility drug / Obtenção de derivados anfifílicos da o-carboximetilquitosana e aplicação no aumento da solubilidade de fármaco pouco solúvel
Atualmente, os polímeros estão entre os excipientes mais utilizados em diversos sistemas terapêuticos devido a suas aplicações e biocompatibilidade. A quitosana (poli- -(1-4)D-glucosamina) é um derivado hidrolisado da quitina, de fácil obtenção, com muitas aplicações industriais na área de biomateriais, alimentos, cosméticos e medicamentos. Nest
Publicado em: 2008
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6. Síntese de Surfactantes Derivados da D-ribonolactona
Surfactants are amphiphilic compounds widely used in cosmetics, food and paint industries. The need for products obtained from natural raw materials instead of petroleum derivatives has led searchers, to the development “natural surfactants” derivated from carbohydrates, biodegradable and atoxic. In this work, we describe the preparation of amphi
Publicado em: 2007
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7. SÍNTESE DE COMPOSTOS ANFIFÍLICOS DERIVADOS DE δ-D-GLICONOLACTONA, POTENCIAIS AGENTES SURFACTANTES
Surfactants are amphiphilic molecules widely used in many industries. A constant need for products obtained from natural raw materials instead of petroleum derivatives has led to a lot of studies on developing natural surfactants derivative from carbohydrates. These compounds are versatile, biodegradable and introduce a wide range of applications, awake the
Publicado em: 2006
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8. Inhibition of entry of the lipid-containing bacteriophage PR4 by fatty acid derivatives.
Amphiphilic fatty acid derivatives having a 14- to 20-carbon cis-unsaturated alkyl chain were found to be potent inhibitors of the entry process of the lipid-containing bacteriophage PR4.
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9. ORIENTATION AND MOTION OF AMPHIPHILIC SPIN LABELS IN MEMBRANES*
The paramagnetic resonance spectra of N-oxyl-4′,′-dimethyloxazolidine derivatives of 12-ketostearic acid, 5-ketostearic acid, 5-ketotricosanoic acid, and 5α-androstan-3-one-17β-ol have been observed in sonicated phospholipid dispersions, the walking-leg nerve fibers of Homarus americanus, and in erythrocytes oriented by hydrodynamic shear. The preferre
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10. Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.
Lactococcus lactis possesses an ATP-dependent drug extrusion system which shares functional properties with the mammalian multidrug resistance (MDR) transporter P-glycoprotein. One of the intriguing aspects of both transporters is their ability to interact with a broad range of structurally unrelated amphiphilic compounds. It has been suggested that P-glycop
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11. Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols.
Derivatives of one triterpene family, the hopane family, are widely distributed in prokaryotes; they may be localized in membranes, playing there the same role as sterols play in eukaryotes, as a result of their similar size, rigidity, and amphiphilic character. Their biosynthesis embodies many primitive features compared to that of sterols and could have ev
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12. Interaction between model membranes and a new class of surfactants with antioxidant function.
The effect of two series of amphiphilic quaternary ammonium salts on some properties of phospholipid membranes was studied. The compounds of one series, N-benzyl-N,N-dimethyl-N-alkyl ammonium bromides, exert a destructive effect on membranes and are treated as reference compounds. The compounds of the other series, N-(3,5-di-t-butyl-4-hydroxy)benzyl-N,N-dime