Amlodipine
Mostrando 13-23 de 23 artigos, teses e dissertações.
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13. Estudo duplo-cego e randomizado para avaliar a eficácia e a tolerabilidade da combinação fixa Anlodipina/Ramipril comparada ao Anlodipino isolado em pacientes hipertensos. / An 18-Week, Prospective, Randomized, Double-Blind, Multicenter Study of Amlodipine/Ramipril Combination Versus Amlodipine Monotherapy in the Treatment of Hypertension: The Assessment of Combination Therapy of Amlodipine/Ramipril (ATAR) Study.
Introdução: A utilização de anti-hipertensivos com diferentes mecanismos de ação em combinação fixa pode oferecer vantagens na adesão ao tratamento, na eficácia e na tolerabilidade. A combinação de um bloqueador dos canais de cálcio com um inibidor da enzima conversora da angiotensina pode reduzir a incidência de edema periférico, alem de agir
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/06/2009
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14. Estudo de farmacocinetica comparativa de uma formulação de amlodipina + maleato de enalapril versus uma formulação de amlodipina e versus uma formulação de maleato de enalapril em voluntarios sadios de ambos os sexos / Comparative pharmacokinetics study of a formulation of amlodipine + enalapril versus an enalapril maleate formulation in healthy volunteers of both genders
Introduction: Based on evidence of studies showing that in 2/3 of the cases of hypertension monotherapy is not enough to reach pressure reduction and facing the necessity of a more rigorous control, there is a clear current trend to the early introduction of a combined therapy of anti-hypertensive drugs as first pharmacological measure. These associations of
Publicado em: 2009
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15. Effects of the calcium channel blocker amlodipine on bone healing of a surgical defect in the mandibular ramus of rats / Efeitos do bloqueador de canais de cálcio amlodipina na reparação óssea em defeito cirúrgico no ramo mandibular de ratos
Os anti-hipertensivos bloqueadores de canais de cálcio, por interferirem no transporte de cálcio através das membranas celulares, podem afetar muitos processos metabólicos, incluindo o metabolismo ósseo. O objetivo deste estudo foi avaliar, de forma radiográfica, histológica e bioquímica, os efeitos do bloqueador de canais de cálcio amlodipina no pr
Publicado em: 2009
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16. Amlodipine and diclofenac interaction on leukocyte behavior in spontaneously hypertensive rats (SHR) and normotensive wistar rats. / Interação anlodipina/diclofenaco sobre o comportamento leucocitário em ratos espontaneamente hipertensos (SHR) e ratos wistar normotensos.
Anlodipina e diclofenaco podem ser combinados de forma que o potencial de interação é alto. Investigamos se anlodipina interfere com o efeito antimigratório do diclofenaco em ratos espontaneamente hipertensos (SHR) e ratos wistar. Os ratos foram tratados (15 dias) com diclofenaco e anlodipina, juntos ou separadamente. A migração leucocitária foi estud
Publicado em: 2008
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17. DEVELOPMENT AND VALIDATION OF METHODOLOGIES FOR ANALYSIS OF AMLODIPINE BESILATE IN FARMACEUTICAL DOSAGE FORMS / DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIA PARA ANÁLISE DE BESILATO DE ANLODIPINO EM FORMAS FARMACÊUTICAS
Neste trabalho foram validadas metodologias para determinação de besilato de anlodipino em comprimidos e cápsulas. Os métodos utilizados para quantificação do fármaco foram: cromatografia líquida (CL) e espectrofotometria na região do ultravioleta. O sistema por CL foi conduzido isocraticamente em temperatura ambiente controlada com coluna de fase r
Publicado em: 2005
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18. Estudos de bioequivalencia de duas formulações comerciais de Nimodipina e Ambodipina
Objectíve: This thesis had as objective to evaluate the bioequivalence through the pharmacokinetic and pharmacodynamic of two comercial formulations of two Calcium Blockers, Amlodipine (Biosintética CordareneR tablets 5 mg vs Pfizer NorvascR tablets 5 mg) and Nimodipine (Biosintética OxigenR tablets 90 mg vs Bayer NimotopR tablets 90 mg). It was selected
Publicado em: 1997
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19. In vitro and in vivo potentiation of chloroquine against malaria parasites by an enantiomer of amlodipine.
A combination of chloroquine and amlodipine, a derivative of 1,4-dihydropyridine calcium channel blocker, was tested against Plasmodium falciparum in vitro and P. yoelii in mice. The dextrorotary enantiomer of amlodipine, practically devoid of calcium channel blocking action, increased chloroquine accumulation inside the infected mouse erythrocytes and poten
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20. Acute pulmonary vasodilatory properties of amlodipine in humans with pulmonary hypertension.
OBJECTIVE: Calcium antagonists are the only oral vasodilators shown to influence mortality in primary pulmonary hypertension, but the high doses required are often poorly tolerated. Amlodipine is a novel, relatively well tolerated, calcium antagonist. It has not been previously tested in humans with pulmonary hypertension. DESIGN: Calcium antagonists are cla
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21. Benefits and side effects of blood pressure lowering treatment: what was wrong with doxazosin in the ALLHAT?
The lowering of high blood pressure is supposed to protect target organs from hypertensive damage. The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial was designed to compare the cardioprotective properties of three antihypertensives from different classes (lisinopril, amlodipine and doxazosin) with chlorthalidone. Despite effecti
BioMed Central.
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22. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.
The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis of various diseases, including atheroscler
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23. Ca(2+)-channel blockers modulate expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor genes stimulated by platelet-derived growth factor.
The effects of Ca(2+)-channel blockers (amlodipine, nifedipine, nitrendipine, and verapamil) on expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1.88) and low density lipoprotein receptor (LDL-R) genes stimulated by recombinant platelet-derived growth factor BB isomer (PDGF-BB) were evaluated in human skin fibroblasts. The drug