Alu Insertions
Mostrando 1-12 de 21 artigos, teses e dissertações.
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1. Research of the origin of a particular Tunisian group using a physical marker and Alu insertion polymorphisms
The aim of this study was to show how, in some particular circumstances, a physical marker can be used along with molecular markers in the research of an ancient people movement. A set of five Alu insertions was analysed in 42 subjects from a particular Tunisian group (El Hamma) that has, unlike most of the Tunisian population, a very dark skin, similar to t
Genetics and Molecular Biology. Publicado em: 08/07/2011
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2. Worldwide genetic variation at the 3´-UTR region of the LDLR gene : possible influence of natural selection
The low density lipoprotein receptor gene (LDLR) contains many Alu insertions, and is especially Alu-rich at its 3 -untranslated region (3 -UTR). Previous studies suggested that the LDLR 3 -UTR could regulate gene expression by the stabilization of its mRNA. Given the faster Alu evolutionary rate, and wondering about its consequences in a possibly regulatory
Publicado em: 2011
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3. Estimating genomic instability mediated by Alu retroelements in breast cancer
Alu-PCR is a relatively simple technique that can be used to investigate genomic instability in cancer. This technique allows identification of the loss, gain or amplification of gene sequences based on the analysis of segments between two Alu elements coupled with quantitative and qualitative analyses of the profiles obtained from tumor samples, surgical ma
Genetics and Molecular Biology. Publicado em: 23/01/2009
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4. African origin of human-specific polymorphic Alu insertions.
Alu elements are a family of interspersed repeats that have mobilized throughout primate genomes by retroposition from a few "master" genes. Among the 500,000 Alu elements in the human genome are members of the human-specific subfamily that are not fixed in the human species; that is, not all chromosomes carry an Alu element at a particular locus. Four such
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5. Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats.
Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat beta-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maint
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6. Differential Alu Mobilization and Polymorphism Among the Human and Chimpanzee Lineages
Alu elements are primate-specific members of the SINE (short interspersed element) retroposon family, which comprise ∼10% of the human genome. Here we report the first chromosomal-level comparison examining the Alu retroposition dynamics following the divergence of humans and chimpanzees. We find a twofold increase in Alu insertions in humans in comparison
Cold Spring Harbor Laboratory Press.
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7. Alu-Containing Exons are Alternatively Spliced
Alu repetitive elements are found in ∼1.4 million copies in the human genome, comprising more than one-tenth of it. Numerous studies describe exonizations of Alu elements, that is, splicing-mediated insertions of parts of Alu sequences into mature mRNAs. To study the connection between the exonization of Alu elements and alternative splicing, we used a dat
Cold Spring Harbor Laboratory Press.
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8. Widespread RNA Editing of Embedded Alu Elements in the Human Transcriptome
More than one million copies of the ∼300-bp Alu element are interspersed throughout the human genome, with up to 75% of all known genes having Alu insertions within their introns and/or UTRs. Transcribed Alu sequences can alter splicing patterns by generating new exons, but other impacts of intragenic Alu elements on their host RNA are largely unexplored.
Cold Spring Harbor Laboratory Press.
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9. Amplification dynamics of human-specific (HS) Alu family members.
We have investigated the distribution of several recently inserted Alu family members within representatives of diverse human groups. Human population studies using 65 unrelated human DNA samples, as well as a familial study to test inheritance, showed that individual Alu family members could be divided into three groups. The first group consisted of relativ
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10. Structure and variability of recently inserted Alu family members.
The HS subfamily of Alu sequences is comprised of a group of nearly identical members. Individual subfamily members share 97.7% nucleotide identity with each other and 98.9% nucleotide identity with the HS consensus sequence. Individual subfamily members are on the average 2.8 million years old, and were probably derived from a single source 'master' gene so
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11. Whole-genome experimental identification of insertion/deletion polymorphisms of interspersed repeats by a new general approach
A new experimental technique for genome-wide detection of integration sites of polymorphic retroelements (REs) is described. The technique allows one to reveal the absence of a retroelement in an individual genome provided that this retroelement is present in at least one of several other genomes under comparison. Since quite a number of genomes are compared
Oxford University Press.
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12. Active Alu Element “A-Tails”: Size Does Matter
Long and short interspersed elements (LINEs and SINEs) are retroelements that make up almost half of the human genome. L1 and Alu represent the most prolific human LINE and SINE families, respectively. Only a few Alu elements are able to retropose, and the factors determining their retroposition capacity are poorly understood. The data presented in this pape
Cold Spring Harbor Laboratory Press.