Alloantibodies
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Maternal-fetal alloimmunization: perinatal outcomes in a reference hospital in Northeastern Brazil
SUMMARY OBJECTIVE: To assess the prevalence of maternal alloantibodies in pregnant women at a maternity hospital in northeastern Brazil and describe their perinatal outcomes. METHODS: A retrospective cohort study reviewed maternal and newborn medical records between January 2017 and October 2018 to assess for the presence of maternal alloantibodies. RESUL
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Red blood cell alloantibodies and autoantibodies: different presentation, same physiopathology
Hematol., Transfus. Cell Ther.. Publicado em: 2018-06
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3. Clinical and epidemiological profile of alloimmunized and autoimmunized multi-transfused patients against red blood cell antigens in a blood center of Minas Gerais
ABSTRACT Background: The large diversity of red blood cell antigens favors, especially in multi-transfused patients, the occurrence of autoimmunization and alloimmunization with the risk of hemolytic transfusion reactions. Thus, this study aimed to determine the rates of alloimmunization and autoimmunization in these individuals, as well as the types of all
Hematol., Transfus. Cell Ther.. Publicado em: 2018-06
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4. Transfusion management for patients taking an anti-CD38 monoclonal antibody
Abstract Introduction: Pre-transfusion tests, essential for the release of blood components, may be affected by drugs. Monoclonal antibodies represent a class of medications increasingly used in the clinical practice, with anti-CD38 monoclonal antibodies (daratumumab) being a promising resource in the treatment of refractory myeloma. This monoclonal antibod
Hematol., Transfus. Cell Ther.. Publicado em: 2018-03
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5. Importance of immune response genes in hemophilia A
Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII cau
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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6. Molecular matching of red blood cells is superior to serological matching in sickle cell disease patients
OBJECTIVE: To evaluate the usefulness of DNA methods to provide a means to precisely genotypically match donor blood units for the antigen-negative type of 35 sickle cell disease patients<. METHODS: Red blood cell units were investigated for ABO, D, C, c, E, e, K, Fyª, Fy b, Jkª, Jk b, S, s, Diª and RH variants by performing a molecular array (Human Eryth
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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7. Identification of platelet refractoriness in oncohematologic patients
OBJECTIVES: To identify the occurrence and the causes of platelet refractoriness in oncohematologic patients. INTRODUCTION: Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of oncohematologic patients and is not routinely investigated in most Brazilian services. METHODS: Forty-four ep
Clinics. Publicado em: 2011
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8. Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1
O objetivo deste estudo foi avaliar a presença de aloanticorpos anti-HLA classe I em pacientes infectados pelo HIV-1 e relacioná-la aos diferentes cursos clínicos da doença. Amostras de sangue de 145 indivíduos HIV positivo foram coletadas em tubos com EDTA. A infecção pelo HIV-1 foi confirmada por teste ELISA e a presença de aloanticorpos anti-HLA c
Brazilian Archives of Biology and Technology. Publicado em: 2010-02
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9. Fenotipagem e aloimunização eritrocitária em portadores de anemia falciforme atendidos no Hemocentro de Alagoas / Erythrocyte phenotyping and alloimmunization in patients with sickle cell anemia assisted at HEMOAL from Alagoas
Objetivo: Determinar a imunofenotipagem eritrocitária em doadores de sangue e em pacientes com anemia falciforme (SS) atendidos no Hemocentro de Alagoas, além de descrever a frequência e os fatores associados à aloimunização eritrocitária. Método: Estudo transversal realizado com 102 pacientes com anemia falciforme (SS) e 100 doadores de sangue. Estu
Publicado em: 2010
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10. Avaliação de diferentes metodologias laboratoriais para detecção de aloanticorpos plaquetários. Determinação da prevalência e importância clínica destes aloanticorpos em pacientes transfundidos / Evaluation of different methodologies for platelet alloantibodies detection. Clinical impact and prevalence of platelet antibodies in transfused patients.
A aloimunização contra antígenos plaquetários é um dos grandes desafios no tratamento de pacientes refratários à transfusão de plaquetas. OBJETIVOS: avaliar o desempenho de metodologias mais utilizadas em laboratórios de referência internacional para a pesquisa de anticorpos plaquetários (PAP); verificar a prevalência destes anticorpos na nossa p
Publicado em: 2008
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11. Anti-HLA and Anti-Neutrophils Alloantibodies Study in Female Blood Donors. / Estudo de aloanticorpos anti-HLA e anti-neutrófilos em doadoras de sangue
Objetivos: O estudo teve como objetivo determinar a prevalência e a especificidade de anticorpos anti-HLA e a prevalência de anti-neutrófilos em doadoras de sangue brasileiras e avaliar o impacto da exclusão de doadoras multíparas positivas da doação de sangue. Métodos: Foram estudadas amostras de soro de 350 doadoras distribuídas em quatro grupos d
Publicado em: 2008
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12. Risk factors for alloimmunization by patients with sickle cell disease
Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined. Transfusion records and medical charts of 828 SCD patients who had been transfused and followed at the Belo Horizonte Blood Center, Belo Horizo
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-05