Allelic Expression
Mostrando 13-24 de 473 artigos, teses e dissertações.
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13. Avaliação dos efeitos de polimorfismos e da origem parental do alelo na expressão de genes candidatos à característica maciez da carne em bovinos da raça Nelore
Tenderness is the main trait appreciated by consumers of bovine meat, however Nellore animals that comprise the largest part of Brazilian cattle, have lower tenderness when compared with European animals. In this way, it is essential understand the variability of genes associated to tenderness as well as their mechanisms of allelic expression, considering th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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14. Differential allelic expression of IL13 and CSF2 genes associated with asthma
An important area of genetic research is the identification of functional mechanisms in polymorphisms associated with diseases. A highly relevant functional mechanism is the influence of polymorphisms on gene expression levels (differential allelic expression, DAE). The coding single nucleotide polymorphisms (SNPs) CSF2rs25882 and IL13rs20541 have been assoc
Genetics and Molecular Biology. Publicado em: 02/08/2012
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15. Comparative mapping reveals quantitative trait loci that affect spawning time in coho salmon (Oncorhynchus kisutch)
Spawning time in salmonids is a sex-limited quantitative trait that can be modified by selection. In rainbow trout (Oncorhynchus mykiss), various quantitative trait loci (QTL) that affect the expression of this trait have been discovered. In this study, we describe four microsatellite loci associated with two possible spawning time QTL regions in coho salmon
Genetics and Molecular Biology. Publicado em: 2012
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16. Caracterização de determinantes genéticos envolvidos na qualidade industrial e nutricional do fruto de tomate / Characterization of genetic determinants involved in industrial and nutritional quality of tomato fruit
This thesis addresses tomato fruit metabolism analysis by using three complementary approaches: i) the identification of candidate genes co-located with QTL previously described from metabolic profiles of S. lycopersicum (cv. M82) and S. pennellii introgressed lines, associated with industrial and nutritional quality traits; ii) the structural analyses of th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2011
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17. Análise morfológica, bioquímica e genética do brilho do tegumento em variedades de feijoeiro (Phaseolus vulgaris L.) / Morphological, biochemical and genetic analysis of seed coat shininess in common bean varieties (Phaseolus vulgaris L.)
Several characteristics interfere in acceptability of common bean varieties (Phaseolus vulgaris L.) by consumers, like seed coat shininess. Generally, varieties with shiny seed coat are rejected by consumers due to their difficult cooking. However, shininess could confer resistance to insects attak and also pathogens to the seed, giving an advantage for this
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/06/2011
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18. Duffy Genotype and Clinical Manifestations Severity in Sickle Cell Anemia / Genótipo Duffy e Gravidade das Manifestações Clínicas na Anemia Falciforme
INTRODUCTION: Sickle cell anemia (SCA) presents with large clinical variability and previous studies suggest that genetic polymorphisms may act as complications predictors. The Duffy antigen appears to play an important role in the removal of inflammatory chemokines from the circulation, suggesting that Duffy-Negative individuals have lower clearance of cyto
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/03/2011
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19. TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness
BACKGROUND: The susceptibility to adverse outcome from critical illness (occurrence of sepsis, septic shock, organ dysfunction/failure, and mortality) varies dramatically due to different degrees of inflammatory response. An over expression of tumor necrosis factor alpha (TNF-α) can lead to the progression of the inflammatory condition. OBJECTIVE: We assess
Brazilian Journal of Infectious Diseases. Publicado em: 2011-06
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20. Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population
Parasites are accountable for driving diversity within immune gene families. We identified and investigated regulatory single nucleotide polymorphisms (SNPs) in the promoter regions of the tumor necrosis factor receptor superfamily member 18 (TNFRSF18) gene by direct sequencing in a group of male Gabonese individuals exposed to a wide array of parasitic dise
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-05
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21. Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population
Parasites remain competent invaders of host immunity. Their invasion strategies have proven to impact immunorelevant genes leading to diversity among gene families. We focussed on signal transducer and activator of transcription (STAT6) factor that plays a fundamental role in signal transduction and activation of transcription. Recent studies have highlighte
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-02
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22. Frequency of genetic polymorphisms of PXR gene in the Brazilian population
INTRODUCTION: PXR polymorphisms have been implicated in modulating CYP3A4 and PXR expression, potentially accounting for interindividual differences in drug metabolism. The prevalence of PXR polymorphisms varies among ethnic groups and data on the allelic distribution in the highly mixed Brazilian population is lacking. The aim of this study was to analyze g
Clinics. Publicado em: 2011
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23. ABCB1 C1236T, G2677T/A and C3435T polymorphisms in systemic lupus erythematosus patients
P-glycoprotein (Pgp), the ABCB1 gene product, acts as an efflux pump that transports a large variety of substrates and is a mechanism of cell protection against xenobiotics. An increasing number of studies have shown that some ABCB1 polymorphisms may affect Pgp expression and activity, as well as affecting the development and susceptibility to diseases and p
Publicado em: 2010
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24. Análise de expressão e splicing alternativo do gene Mdh-1 de Apis mellifera L. (Hymenoptera: Apidae)
Mdh-1 enzyme locus coding for cytoplasmic malate dehydrogenase has three common alleles Mdh-1100 (F), Mdh-180 (M) e Mdh-165 (S) and it has been extensively used as racial marker in populational studies of Apis mellifera. Additional isoforms are detected by electrophoretic analysis during ontogenetic development of A. mellifera, indicating differential expres
Publicado em: 2010