Air Pouch Model
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Individual variation is the key to the development of a vaccine against Staphylococcus aureus: a comparative study between mice lineages
Bacterial infections occur worldwide and are a major public health problem. Among pathogens, Staphylococcus aureus is the main causative agent of bacterial diseases in the world. This study aimed to evaluate which components of the immune system could act protectively against a S. aureus infection in intradermally immunized mice. C57BL/6 and A/j mice were im
Braz J Med Biol Res. Publicado em: 26/03/2018
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2. Potencial antiinflamatório do extrato aquoso de Echinodorus macrophyllus e de suas frações em modelo de inflamação aguda / Anti-inflammatory potential of aqueous extract of Echinodorus macrophyllus and its fractions in acute inflammation model
A Echinodorus macrophyllus (Alismataceae), conhecida como chapéu de couro no Brasil, é usada popularmente para tratar doenças reumáticas e inflamatórias. Neste trabalho, foram avaliados os efeitos antiinflamatórios do extrato aquoso de E. macrophyllus (EAEm) e suas frações etanólicas no modelo murino de air pouch. Para a obtenção das frações, 7
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/02/2011
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3. CinÃtica e recrutamento celular induzidos por Leishmania chagasi no modelo da bolsa de ar subcutÃnea em hamsters / Kinetics and cellular recruitment induced by Leishmania chagasi in the model of the subcutaneous air pouch in hamsters
Quando fazem o repasto sanguÃneo, fÃmeas do flebotomÃneo inoculam promastigotas de Leishmania junto com a saliva no lago sanguÃneo formado pelo traumatismo da probÃscida do inseto, na derme do hospedeiro mamÃfero. O sistema imunolÃgico do hospedeiro, na tentativa de controlar a infecÃÃo, recruta leucÃcitos para o sÃtio inflamatÃrio da inoculaÃÃ
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/09/2009
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4. Estudo "in vivo" da atividade antiinflamatoria de inibidores de secreção acida
Helicobacter pylori infection and the administration of nonsteroidal antiinflammatory drugs are the main causes of gastric ulcerations. In the clinical setting, patients with gastric ulcerations are treated with histamine-2 (H2) receptor antagonists and proton pump inhibitors (PPI) to neutralize or reduce the acid secretion. Recently, studies have shown that
Publicado em: 2005
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5. Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis.
Using a rat air pouch model of red cell promoted allergic inflammation, we have investigated the relation between ferritin synthesis and iron deposition in pouch wall lining cells. These cells have structural and immunohistochemical similarities to human synovial intimal cells and studies of them are pertinent to the clinical situation. In control air pouch
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6. Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch.
The hypothesis that haem iron derived from synovial microbleeding has a proinflammatory effect on the synovial membrane was tested by adding autologous whole blood and fractions derived from it to a naturally remitting rat air pouch model of allergic inflammation. The induction of such a subcutaneous air pouch produces a cavity lined by mesenchymal cells com
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7. Inhibition of Group A Streptococcus Infection by Carboxyfullerene
The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes-induced death and skin injury were inhibited dose dependently by carboxyfullerene. Administratio
American Society for Microbiology.
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8. Studies on the clearance of calcium pyrophosphate crystals from facsimile synovium.
Calcium pyrophosphate dihydrate crystals have been injected into the air pouch model of facsimile synovium. At various time intervals after crystal injection both infiltrating exudate cells and lining tissue were examined for the presence of crystalline material. The results show that the crystals are initially engulfed by mononuclear cells and to a lesser e
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9. The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the hypothesis that the antiphlogistic effects of methotrexate result from its capacity to promote intracellular accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) that, under conditions of cell injury, increases local
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10. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.
We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of the induction of COX-2 mRNA and protein coincided with the p
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11. Mast cells in newly formed lining tissue during acute inflammation: a six day air pouch model in the mouse.
Connective tissue mast cells were topographically and quantitatively studied in the newly formed lining tissue of six day old air pouches induced in the dorsal surface of mice. The results showed that the number of mast cells in the cavities innermost lining increased after injection of carrageenan into the cavity. Degranulation of mast cells was also observ
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12. Lack of correlation between in vitro and in vivo effects of low density lipoprotein on the inflammatory activity of monosodium urate crystals.
The effect of coating monosodium urate crystals (MSU) with low density lipoprotein (LDL), postulated previously as a major regulator of gouty inflammation, was studied in a neutrophil chemiluminescence (CL) assay and an air pouch model of inflammation induced by MSU. LDL crystalline coating abrogated the neutrophil CL response but, in contrast, had no inhibi