Ah Nmr
Mostrando 13-13 de 13 artigos, teses e dissertações.
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13. Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
The core domain of p53 is extremely susceptible to mutations that lead to loss of function. We analysed the stability and DNA-binding activity of such mutants to understand the mechanism of second-site suppressor mutations. Double-mutant cycles show that N239Y and N268D act as ‘global stability’ suppressors by increasing the stability of the cancer mutan
Oxford University Press.