Agonists And Antagonist Of 5 Ht3 Receptors
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Envolvimento dos receptores 5-HT2c do hipocampo ventral na modulação de estados de ansiedade em ratos
The present study investigated the effects of pharmacological blockade of 5-HT2C receptors of the ventral hippocampus (VH) on anxiety levels of rats induced by 5-HT2C agonists. Ten minutes after intraperitoneal (i.p.) injections of either saline (0.9%) or the 5-HT2C agonist WAY-161503 (3mg/kg), rats were bilaterally microinjected in the VH with saline or wit
Publicado em: 2010
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2. Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao labirinto em cruz elevado promove efeito ansiolítico que é revertido pelo prétratamento local com WAY100635
Research on anxiety often involves the use of animal models for investigation of therapeutic compounds. Thus, the elevated plus maze (EPM) is one of the most commonly model used in research involving anxiety and it has been validated for rats and mice. Serotonin (5-HT) is a neurotransmitter involved not only in anxiety but also in other disorders. Some repor
Publicado em: 2010
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3. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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4. Avaliação do papel dos receptores 5-HT3 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
A exposição de animais a situações aversivas, tais como o labirinto em cruz elevado (LCE), ativa vias serotoninérgicas com projeções para estruturas envolvidas no sistema de defesa tais como, amídala, septo, hipotálamo, hipocampo e substância cinzenta periaquedutal (SCP), produzindo alterações comportamentais que podem ser caracterizadas como ans
Publicado em: 2009
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5. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists.
Serotonin (5-hydroxytryptamine, 5-HT) has been shown to be a neurotransmitter in the enteric nervous system (ENS). Although 5-HT is a mediator of slow excitatory postsynaptic potentials evoked by stimulation of interganglionic connectives, the precise role it plays in the physiology of the gut is unclear. Research has been hampered by an inadequate knowledge
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6. 5-hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells
We studied the distribution of 5-hydroxytryptamine– (5-HT-) containing cells in the guinea pig pancreas and examined the effects of 5-HT on fluid secretion by interlobular pancreatic ducts. The 5-HT–immunoreactive cells with morphological characteristics of enterochromaffin (EC) cells were scattered throughout the duct system and were enriched in islets
American Society for Clinical Investigation.
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7. Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro.
1. The actions of serotonin (5-HT) on pyramidal cells of the CA1 region of the rat hippocampus were characterized using intracellular recording in in vitro brain slices. 2. 5-HT typically evokes a biphasic response consisting of a hyperpolarization which is followed by a longer-lasting depolarization. These effects on membrane potential are accompanied by a
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8. Compared effects of serotonin on cervical and hypoglossal inspiratory activities: an in vitro study in the newborn rat.
1. Experiments were performed on the brain stem-spinal cord preparation of newborn rats, in which the phrenic and hypoglossal nerves continue to show rhythmic respiratory activity in vitro, in order to compare the effects of serotonin (5-HT) on both activities and to analyse the mechanisms responsible for the depression by 5-HT of the hypoglossal activity. 2
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9. Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.
To test the hypothesis that agents activating receptors negatively coupled to adenylyl cyclase (AC) can stimulate cell proliferation, we have expressed a human alpha 2-adrenergic receptor (alpha 2-C10) in CCL39 cells and studied the effects of alpha 2-agonists on reinitiation of DNA synthesis in quiescent cells. We report that the alpha 2-agonists epinephrin