Adrenocortical Adenoma
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Avaliação de Alterações Cardíacas Subclínicas e Atraso Eletromecânico Atrial por Ecocardiografia com Doppler Tecidual em Pacientes com Incidentaloma Adrenal Não Funcionante
Resumo Fundamento: A maioria das massas adrenais descobertas incidentalmente, denominadas incidentaloma adrenal (IA), são adenomas adrenais não funcionantes. O manejo adequado da IA ainda é um tema de debate, e por isso é necessário investigar suas morbidades associadas. Entretanto, dados referentes a alterações cardíacas morfológicas e funcionais
Arq. Bras. Cardiol.. Publicado em: 11/10/2018
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2. New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of st
Clinics. Publicado em: 2017-06
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3. Importância da via do mevalonato nas neoplasias do córtex adrenal / Importance of mevalonate pathway in adrenocortical tumors
Introdução: A 3-hidroxi-3-metilglutaril coenzima A redutase (HMGCR) é a enzima limitante da via do mevalonato. Esta via, que tem como produto final o colesterol, gera inúmeros subprodutos, como os isoprenóides, essenciais para modificação pós-traducional de várias proteínas envolvidas em proliferação e crescimento celular. Em tecidos esteroidogê
Publicado em: 2011
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4. Análise do gene AIP na acromegalia familial isolada / Analysis of the AIP gene in familial isolated acromegaly
Acromegaly is a rare disfigurating and insidious disease characterized by enlargement of hands, feet and skull bones due to excess of growth hormone (GH) secreted by a pituitary tumor (somatotropinoma). The majority of the cases with acromegaly is sporadic, however it may occur in association with inherited disorders as Multiple Endocrine Neoplasia type 1 (M
Publicado em: 2010
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5. Screening for Cushing's syndrome in obese patients
OBJECTIVES: The aim of this study was to examine the frequency of Cushing's syndrome (CS) in obese patients devoid of specific clinical symptoms of Cushing's syndrome. METHODS: A total of 150 obese patients (129 female, 21 male; mean age 44.41 ± 13.34 yr; mean BMI 35.76 ± 7.13) were included in the study. As a first screening step, we measured 24-h urinary
Clinics. Publicado em: 2010
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6. Tumores renais e adrenais com invasão cardíaca: resultados cirúrgicos imediatos em 14 pacientes
FUNDAMENTO: A ressecção do trombo tumoral em veia cava inferior (VCI) e átrio direito (AD) aumenta a sobrevida do paciente com câncer renal/supra-renal. OBJETIVO: Avaliar a conduta cirúrgica do trombo da VCI e AD no tratamento dos tumores renais e supra-renais. MÉTODOS:De janeiro de 1997 a junho de 2007 foram avaliados, retrospectivamente, 14 pacientes
Arquivos Brasileiros de Cardiologia. Publicado em: 2009-03
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7. Expression profiles of metastasis-related genes in a cohort of childhood and adult adrenocortical tumors / Perfis de expressão de genes relacionados a metástases em uma coorte de pacientes adultos e pediátricos portadores de neoplasias do córtex da supra-renal
Adrenocortical carcinoma (ACC) is a rare neoplasm with a poor prognosis. Although molecular studies have uncovered many aspects of ACC tumorigenesis, little is known about molecular pathways involved in metastatic spread. The objective of our study is to analyze the expression profile of metastasis-related genes in a cohort of metastatic and nonmetastatic ad
Publicado em: 2008
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8. Expression of IGF-II, IGF-IR, SF-1 and DAX-1 genes in pediatric and adult adrenocortical tumors / Expressão dos genes IGF-II, IGF-IR, SF-1 e DAX-1 em tumores adrenocorticais de crianças e adultos
Introduction: The molecular pathogenesis of adrenocortical tumors is heterogeneous and incompletely understood. Insulin-like growth factor II (IGF-II) overexpression has been demonstrated in adult adrenocortical carcinomas. IGF-II exerts its mitogenic effects through interaction with IGF-I receptor (IGF-IR). In addition, steroidogenic factor 1 gene (SF-1) an
Publicado em: 2008
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9. Adrenocortical tumors in children
Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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10. Tumors of the adrenal cortex and Cushing's syndrome.
Fifty-nine patients with Cushing's syndrome, due to adrenocortical tumor, were studied and treated during the period 1953 through 1983 at Vanderbilt University Medical Center. Cushing's syndrome is caused by hypercortisolism that can be due to (1) medicinal use of steroids, (2) excess pituitary secretion of adrenocorticotropin (ACTH) (Cushing's disease), (3)