Administration Intravesical
Mostrando 1-9 de 9 artigos, teses e dissertações.
-
1. Nanopharmaceuticals and Their Applications in Bladder Cancer Therapy: a Mini Review
The primary treatment for high-grade non-muscle invasive bladder cancer (NMIBC) is based on surgery by transurethral resection of bladder tumor (TURBT), followed by intravesical immunotherapy with Bacillus Calmette-Guerin (BCG) to prevent recurrence and to reduce the tumor progression. However, BCG therapy shows several undesirable effects. The current treat
J. Braz. Chem. Soc.. Publicado em: 2018-05
-
2. Potential therapeutic strategies for non - muscle invasive bladder cancer based on association of intravesical immunotherapy with P-MAPA and systemic administration of cisplatin and doxorubicin
ABSTRACT The present study describes the histopathological and molecular effects of P-MAPA (Protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride) intravesical immunotherapy combined with systemic doxorubicin or cisplatin for treatment of non-muscle invasive bladder cancer (NMIBC) in an appropriate animal model. Our results showed an u
Int. braz j urol.. Publicado em: 2016-10
-
3. Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes
ABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesi
An. Acad. Bras. Ciênc.. Publicado em: 01/09/2016
-
4. Are we following the guidelines on non-muscle invasive bladder cancer?
ABSTRACT Objectives To evaluate the clinical practice of non-muscle invasive bladder cancer (NMIBC) treatment in Brazil in relation to international guidelines: Sociedade Brasileira de Urologia (SBU), European Association of Urology (EAU) and American Urological Association (AUA). Materials and Methods Cross-sectional study using questionnaires about uro
Int. braz j urol.. Publicado em: 2016-02
-
5. Influence of oxidative stress on inducing micturition dysfunction following chronic infravesical obstruction and the protective role of an antioxidant diet - association of in vivo and in vitro studies in rats
OBJECTIVE: This study was developed to determine whether the generation of free radicals, induced by ischemia followed by reperfusion in a model of chronic intravesical obstruction in rats, would lead to damage in the detrusor. It also investigates the possible protective action of the flavonoid galangin on the tissue lesion induced by lipid peroxidation. MA
Int. braz j urol.. Publicado em: 2012-08
-
6. Intravesical anesthesia for bladder tissue biopsies: comparison of two methods
PURPOSE: To estimate the level of analgesia which can be obtained with simple intravesical instillation of ropivacaine in comparison to the combination of both instillation and subepithelial injection of the same agent. MATERIALS AND METHODS: Fifty-two patients were randomized in order that half (26) of them received simple intravesical instillation of ropiv
International braz j urol. Publicado em: 2008-06
-
7. Avaliação do bacilo de Calmette-Guérin recombinante expressando o antígeno S1PT no tratamento do carcinoma urotelial de bexiga em modelo experimental / Evaluation of recombinant bacillus Calmette-Guérin expressing S1PT in the treatment of urothelial bladder carcinoma in an experimental model
Introdução: A imunoterapia intravesical com o bacilo de Calmette-Guérin (BCG) é o tratamento adjuvante de escolha no câncer superficial de bexiga. Recentemente, os estudos do mecanismo imunoterápico do BCG têm permitido identificar as reações imunológicas e os genes associados ao efeito antitumoral, possibilitando a produção de vacinas recombinan
Publicado em: 2008
-
8. A model of hemorrhagic cystitis induced with acrolein in mice
Acrolein is a urinary metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds. A direct cytotoxic effect of acrolein, however, has not yet been demonstrated. In the present study, the effects of intravesical injection of acrolein and mesna, the classical acrolein chem
Brazilian Journal of Medical and Biological Research. Publicado em: 25/09/2006
-
9. Arthritis associated with adjuvant mycobacterial treatment for carcinoma of the bladder.
A patient who developed an inflammatory polyarthritis following intravesical administration of bacillus Calmette-Guérin (BCG) used in the treatment of bladder cancer is described. An inflammatory synovitis comprising predominantly T lymphocytes was demonstrated on synovial biopsy. The synovitis resolved spontaneously within 14 days in this 'human model' of