Adherent Junctions
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Glycans expression and their involvement with the loss of stability of adherens junctions in colorectal cancer cells / Expressão de glicanos e seu envolvimento com a perda da estabilidade das junções aderentes em células de câncer colo-retal
A junção aderente (JA) é um dos principais componentes do complexo juncional apical. Esta juncão é um complexo multiprotéico em que a E-caderina, uma glicoproteína transmembrana, atua como principal mediadora da adesão célula-célula. Sua ancoragem ao citoesqueleto de actina ocorre via proteínas da família das cateninas. Modificações pós-traduc
Publicado em: 2009
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2. Gap Junctions between Photoreceptor Cells in the Vertebrate Retina
In the outer plexiform layer of the retina the synaptic endings of cone cells make specialized junctions with each other and with the endings of rod cells. The ultrastructure of these interreceptor junctions is described in retinas of monkeys, rabbits, and turtles, in thin sections of embedded specimens and by the freeze-fracturing technique. Cone-to-rod jun
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3. Ultrastructure of retinal vessels in diabetic patients.
The ultrastructure of retinal vessels was examined in three eyes from diabetic patients and two eyes from control subjects. In some of the retinal blood vessels of each of the diabetic eyes, the endothelial cytoplasm was thin and had fenestrae. These fenestrations which were seen in both capillaries and venules, were closed by a thin diaphragm. Transendothel
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4. Tumor suppressor gene E-cadherin and its role in normal and malignant cells
E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign
BioMed Central.
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5. Enteropathogenic Escherichia coli decreases the transepithelial electrical resistance of polarized epithelial monolayers.
The mechanisms whereby enteropathogenic Escherichia coli (EPEC) causes diarrhea remain undefined. We found that EPEC caused a decrease in transepithelial electrical resistance across polarized monolayers of Caco-2 and MDCK epithelial cells. This occurred approximately 6 to 10 h after bacterial addition and was reversible if the monolayers were treated with t
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6. Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury
Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The defect was not observed in mice with an endo
National Academy of Sciences.
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7. Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.
Simple epithelial cells are polygonal in shape, polarized in an apical-basal orientation, and organized into closely adherent sheets, characteristics that result from a variety of cellular specializations and adhesive proteins. These characteristics are lost when the epithelia transform during embryogenesis into mesenchymal cells or after neoplasia into inva
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8. Adherence of enterohemorrhagic Escherichia coli strains to a human colonic epithelial cell line (T84).
Enterohemorrhagic Escherichia coli (EHEC) produce Shiga-like toxins and attach to certain tissue culture cells. T84 cells are human colonic carcinoma cells. Unlike previously studied cell lines, T84 cells grown on collagen-coated surfaces polarize and produce tight junctions and desmosomes, forming a colonic epithelial cell layer in vitro. The purpose of thi
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9. Flickering fusion pores comparable with initial exocytotic pores occur in protein-free phospholipid bilayers
For the act of membrane fusion, there are two competing, mutually exclusive molecular models that differ in the structure of the initial pore, the pathway for ionic continuity between formerly separated volumes. Because biological “fusion pores” can be as small as ionic channels or gap junctions, one model posits a proteinaceous initial fusion pore. Beca
National Academy of Sciences.
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10. Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa.
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, and pneumolysin, a hemolytic toxin, is thought to be an important virulence factor. We have studied the interaction of a pneumolysin-sufficient type II S. pneumoniae strain (PL+) and an otherwise identical pneumolysin-deficient derivative (PL-) with human respiratory mucosa in
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11. Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells.
An important step in the pathogenesis of Neisseria meningitidis is the crossing of two cellular barriers, one in the nasopharynx and one in the brain. To approach the mechanisms by which this bacterium can achieve these goals, we studied the interactions between N. meningitidis and a monolayer of polarized tight junction-forming T84 cells grown on filter uni
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12. Multiple roles of β-catenin in controlling the neurogenic niche for midbrain dopamine neurons
Stem cell-based replacement therapy has emerged as a potential strategy to alleviate specific features of movement disorder in Parkinson's disease. However, the current strategy to produce dopamine (DA) neurons from embryonic stem cells has many limitations, including the difficulty of generating DA neurons with high yields. Further insights into the mec
Company of Biologists.