Adenosine A2a Receptor
Mostrando 1-12 de 316 artigos, teses e dissertações.
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1. Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans
Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; how
Braz J Med Biol Res. Publicado em: 02/07/2018
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2. Induction of apoptosis by Moutan Cortex Radicis in human gastric cancer cells through the activation of caspases and the AMPK signaling pathway
Abstract Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa Andrews, Paeoniaceae, has been widely used in traditional medicine therapy. Although it has been shown to possess many pharmacological activities, the molecular mechanisms of its anti-cancer activity have not been clearly elucidated. In the present study, we investigated the pro-apoptot
Rev. bras. farmacogn.. Publicado em: 2017-06
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3. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using
Acta Cir. Bras.. Publicado em: 2016-02
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4. Neuroprotection of Persea major extract against oxygen and glucose deprivation in hippocampal slices involves increased glutamate uptake and modulation of A1 and A2A adenosine receptors
Ischemic stroke is characterised by a lack of oxygen and glucose in the brain, leading to excessive glutamate release and neuronal cell death. Adenosine is produced in response to ATP depletion and acts as an endogenous neuromodulator that reduces excitotoxicity. Persea major (Meins.) L.E. Kopp (Lauraceae) is a medical plant that is indigenous to South Brazi
Rev. bras. farmacogn.. Publicado em: 2013-10
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5. P2X7 receptor mediates activation of microglial cells in prostate of chemically irritated rats
Purpose Evidence shows that adenosine triphosphate (ATP) is involved in the transmission of multiple chronic pain via P2X7 receptor. This study was to investigate the P2X7 and microglial cells in the chronic prostatitis pain. Materials and Methods Rats were divided into control group and chronic prostatitis group (n = 24 per group). A chronic prostatitis
Int. braz j urol.. Publicado em: 2013-04
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6. Vias intracelulares da ação do Sildenafil no diabetes insipidus induzido pelo lítio / Sildenafil action in lithium-induced NDI: intracellular pathway
Patients taking lithium to treat bipolar disorder often present polyuria and urinary concentrating defect. In addition, lithium-treated animals present lower cyclic adenosine monophosphate production in response to vasopressin. Sildenafil (Sil), a phosphodiesterase 5 (PDE5) inhibitor, elevates intracellular cyclic guanosine monophosphate (cGMP) levels, leadi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/06/2012
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7. Leishmania amazonensis prejudica resposta de células dendríticas via inibição da expressão de CD40 mediada por ectonucleotidases e pela ativação do receptor de adenosina A2B / Leishmania amazonensis prejudica resposta de células dendríticas via inibição da expressão de CD40 mediada por ectonucleotidases e pela ativação do receptor de adenosina A2B
Leishmania infections can result in a wide spectrum of clinical manifestations, and the outcome of disease is determined by parasite species and the host immune response. Dendritic cells play an essential role in the modulation of immune response including during Leishmania infection. Extracellular-ATP exhibits pro-inflammatory properties whereas adenosine i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
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8. O impacto da frequência do exercício físico sobre proteínas sinápticas e o comportamento de ratos durante a fase adulta e no envelhecimento
Physical exercise is considered an important alternative in reducing the risk of many diseases and improves the quality of life. These benefits are most evident when the body becomes more vulnerable, either through the natural process of aging or in the onset of neurodegenerative disease. However, the amount of exercise for these benefits is unkwon. Thus, th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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9. Participação do sistema purinérgico no locus coeruleus (LC) no controle cardiorrespiratório e térmico em normocapnia e hipercapnia em ratos não anestesiados
O LC é considerado uma região quimiossensível a CO2/pH em mamíferos e anfíbios, especificamente os neurônios noradrenérgicos. A neuromodulação purinérgica no LC desperta um interesse particular uma vez que a adenosina 5-trifosfato (ATP) atua como neuromodulador em várias áreas do tronco encefálico envolvidas na regulação cardiorrespiratória,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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10. A intrigante bioquímica da niacina: uma revisão crítica
Niacin (nicotinamide, nicotinic acid) interferes on homeostasis, DNA regulation, signaling and longevity. Nicotinic acid reduces synthesis of lipoproteins-apo-B and increases HDL. Its antilipemic action in liver produces: 1) inhibition of DGAT2, with decreased triacylglycerol synthesis, 2) downregulation of the b-chain of adenosine triphosphate synthase, lea
Química Nova. Publicado em: 2011
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11. Efeitos a longo prazo de diferentes separações dos filhotes no período neonatal sobre as genitoras
Esse estudo foi realizado para verificar se a exposição a separações repetidas (por diferentes intervalos de tempo) de mães dos seus filhotes no período neonatal poderiam ser classificadas como indutoras de um estado do tipo deprimido em genitoras. Sessenta ratas Wistar prenhes foram divididas em 3 grupos: controle, separação por 10 minutos e separa�
Publicado em: 2011
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12. EFEITOS AGUDOS DA ASSOCIAÇÃO DE ETANOL E AMINOFILINA EM TESTES COMPORTAMENTAIS E NEUROQUÍMICOS EM CAMUNDONGOS / ACUTE EFFECTS OF ETHANOL AND ASSOCIATION TESTS IN aminophylline behavioral and neurochemical IN MICE
Ethanol effects in central nervous system (CNS) are due to its action in several neurotransmitter systems, changing the existing balance in inhibitory and excitatory pathways. Aminophylline, a methylxanthine with stimulant action, is an adenosine receptor antagonist, and actually used in treatment of asthma and consciousness recovery after long period of ane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/05/2010