Acute Lung Injury
Mostrando 25-36 de 245 artigos, teses e dissertações.
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25. Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinase/Akt pathway
The aim of this study was to investigate the effect of propofol pretreatment on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the role of the phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) pathway in this procedure. Survival was determined 48 h after LPS injection. At 1 h after LPS challenge, the lung wet- to dry-weight ratio was examin
Braz J Med Biol Res. Publicado em: 14/10/2014
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26. Therapeutic effects of compound hypertonic saline on rats with sepsis
Sepsis is one of the major causes of death and is the biggest obstacle preventing improvement of the success rate in curing critical illnesses. Currently, isotonic solutions are used in fluid resuscitation technique. Several studies have shown that hypertonic saline applied in hemorrhagic shock can rapidly increase the plasma osmotic pressure, facilitate the
Braz J Infect Dis. Publicado em: 2014-09
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27. Exogenous normal lymph alleviates lipopolysaccharide-induced acute lung injury through lessening the adhesion molecules
PURPOSE: To evaluate the role of exogenous normal lymph (ENL) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats.METHODS:ALI was induced by the jugular vein injection of LPS (iv, 15 mg/kg) in rats of the LPS and LPS+ENL groups within 15 min, then, ENL without cell components (5 ml/kg) was infused at the speed of 0.5 ml per minute in the LPS+
Acta Cir. Bras.. Publicado em: 2014-05
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28. Immunohistochemical detection of virus through its nuclear cytopathic effect in idiopathic interstitial pneumonia other than acute exacerbation
Idiopathic interstitial pneumonias include complex diseases that have a strong interaction between genetic makeup and environmental factors. However, in many cases, no infectious agent can be demonstrated, and these clinical diseases rapidly progress to death. Theoretically, idiopathic interstitial pneumonias could be caused by the Epstein-Barr virus, cytome
Braz J Med Biol Res. Publicado em: 18/11/2013
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29. Ethyl-pyruvate reduces lung injury matrix metalloproteinases and cytokines and improves survival in experimental model of severe acute pancreatitis
PURPOSE: To investigate if the ethyl-pyruvate solution could reduce mortality in AP and/or diminish the acute lung injury. METHODS: Forty male rats, weighing between 270 to 330 grams were operated. An experimental model of severe AP by injection of 0.1ml/100g of 2.5% sodium taurocholate into the bilio-pancreatic duct was utilized. The rats were divided into
Acta Cir. Bras.. Publicado em: 2013-08
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30. Propofol exerts anti-inflammatory effects in rats with lipopolysaccharide-induced acute lung injury by inhibition of CD14 and TLR4 expression
We investigated the effect of propofol (Prop) administration (10 mg kg-1 h-1, intravenously) on lipopolysaccharide (LPS)-induced acute lung injury and its effect on cluster of differentiation (CD) 14 and Toll-like receptor (TLR) 4 expression in lung tissue of anesthetized, ventilated rats. Twenty-four male Wistar rats were randomly divided into three groups
Braz J Med Biol Res. Publicado em: 15/03/2013
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31. Ischemic preconditioning attenuates remote pulmonary inflammatory infiltration of diabetic rats with an intestinal and hepatic ischemia-reperfusion injury
PURPOSE: To assess ischemic preconditioning (IPC) effects in pulmonary lesion in intestinal and hepatic ischemia-reperfusion (IR) injury models using diabetic rats. METHODS: Diabetes (DM) was induced in 28 male Wistar rats by alloxan (42 mg/kg, IV). After 28 days, severe DM rats were submitted to intestinal or hepatic IR injury with or without IPC. Intestina
Acta Cir. Bras.. Publicado em: 2013-03
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32. Avaliação da resposta inflamatória pulmonar de suínos submetidos a lesão pulmonar aguda induzida por ácido clorídrico e tratados com solução salina hipertônica / Lung inflammatory response in pigs submitted to acute pulmonary injury by hydrochloric acid and treated with hypertonic saline
INTRODUÇÃO: A lesão pulmonar aguda (LPA) decorrente de aspiração do conteúdo gástrico é freqüente em pacientes com nível de consciência comprometido e depressão dos reflexos de vias aéreas. A solução salina hipertônica (HS) a 7,5% apresenta resultados ainda controversos quanto ao seu potencial efeito protetor na resposta inflamatória pulmona
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/11/2012
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33. Efeitos fisiológicos da ventilação de alta frequência usando ventilador convencional em um modelo experimental de insuficiência respiratória grave / Physiological effects of high frequency ventilation with conventional ventilator in an experimental model of severe respiratory failure
Introduction: Acute respiratory distress syndrome (ARDS) has a high incidence and mortality between critical ill patients. The mechanical ventilation is the most important support for these patients with ARDS. However, until now there is an important debate about how is the best ventilatory strategy to use, because the mechanical ventilation if not well set
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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34. Imagem e mecânica pulmonar regional em duas estratégias protetoras de ventilação mecânica (ARDSNet versus PEEP ajustada pela tomografia de impedância elétrica): um estudo de longo prazo em modelo experimental / Image and regional lung mechanics in two protective ventilatory strategies (ARDSNet versus PEEP adjusted by electrical impedance tomography): a long term experimental model study
Introdução: As estratégias ventilatórias protetoras têm contribuído para a redução da letalidade da Síndrome do Desconforto Respiratório Agudo (SDRA), mas ainda está em debate qual, entre as diversas existentes, é a mais eficaz. A estratégia ARDSNet, muito utilizada na prática clínica, prioriza a redução do volume corrente para minimizar a h
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/04/2012
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35. Comparação entre as soluções de preservação pulmonar Perfadex® e LPD-G nacional em pulmões com um modelo de perfusão pulmonar ex vivo / Comparison between lung preservation solutions Perfadex and LPD-G with a ex vivo lung perfusion model
INTRODUÇÃO: As técnicas de preservação pulmonar visam a melhorar a qualidade do enxerto e aumentar sua tolerância ao período de isquemia fria. A técnica mais usada atualmente consiste na perfusão da artéria pulmonar com Perfadex. O alto custo associado à importação dessa solução e as dificuldades logísticas dos portos e aeroportos brasileiros
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/01/2012
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36. Detecção da abertura e colapso alveolar durante o ciclo ventilatório através da tomografia de impedância elétrica / Tidal recruitment detection by Electrical Impedance Tomography in an experimental model
Introdução: A Abertura e fechamento alveolar a cada ciclo respiratório (TR) é mecanismo de lesão pulmonar associada à ventilação mecânica. É frequente, especialmente em pacientes com lesão pulmonar aguda/ sindrome do desconforto respiratório agudo, mas pode ocorrer em pulmões normais, devido à pressão expiratória final positiva (PEEP) insufic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/11/2011